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A kind of traditional Chinese medicine composition for treating hypertension

A composition and high blood pressure technology, which is applied in the direction of drug combination, medical raw materials derived from mollusks, and pharmaceutical formulas, can solve problems such as kidney damage, disability, and exacerbation of hypertensive patients, and achieve obvious improvement in symptoms and lower blood pressure. Good effect, no toxic side effects

Active Publication Date: 2017-10-31
JILIN ZIXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, many hypertensive patients cannot adhere to medication and aggravate their condition
In addition, Western medicine is the main treatment for high blood pressure clinically, but there are side effects such as dizziness and headache, and long-term substandard blood pressure in hypertensive patients can lead to target organ damage, which is extremely harmful to patients, and severe cases can cause disability and death
According to statistics, the mortality rate of hypertension combined with renal damage in the United States is 10%, and there are not a few cases of hypertension combined with renal damage in my country, and the proportion of salt-sensitive hypertension in my country is large (accounting for about 60%). The rate is low, which will undoubtedly cause damage to target organs such as the kidney

Method used

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  • A kind of traditional Chinese medicine composition for treating hypertension
  • A kind of traditional Chinese medicine composition for treating hypertension
  • A kind of traditional Chinese medicine composition for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 Chinese medicine composition of the present invention

[0039] Traditional Chinese medicine composition 1 of the present invention: rhubarb 11g, Polygonum multiflorum 11g, Honeysuckle 16g, Astragalus 21g, Motherwort 10g, Angelica 21g, Polygonatum 16g, Prunella vulgaris 21g, Uncaria 11g, Radix Paeoniae Alba 11g, Plantain 10g, Chrysanthemum 3g, Hawthorn 10g , Cassia 16g, Polygonum cuspidatum 10g.

[0040] Chinese medicine composition 2 of the present invention: rhubarb 19g, Polygonum multiflorum 19g, Honeysuckle 29g, Astragalus 39g, Motherwort 19g, Angelica 39g, Polygonatum 24g, Prunella vulgaris 29g, Uncaria 29g, Radix Paeoniae Alba 19g, Plantain 39g, Chrysanthemum 7g, Hawthorn 19g , Cassia 24g, Polygonum cuspidatum 16g.

[0041] Chinese medicine composition 3 of the present invention: rhubarb 15g, Polygonum multiflorum 15g, Honeysuckle 23g, Astragalus 30g, Motherwort 11g, Angelica 30g, Polygonatum 20g, Prunella vulgaris 25g, Uncaria 25g, Radix Paeoniae Al...

Embodiment 2

[0042] The preparation of embodiment 2 Chinese medicine composition of the present invention

[0043] Due to the many medicinal flavors and complex ingredients, including fat-soluble active ingredients and water-soluble active ingredients, it was decided to use a fixed extraction ethanol concentration of 90% and twice alcohol extraction times and water extraction times. Astragaloside IV, the main active ingredient contained in Astragalus membranaceus, was used as an index, and with reference to the yield of the extract, the orthogonal test method was used to investigate the effect of the amount of alcohol added, the amount of water added, and the extraction time on the extraction effect.

[0044] Table 1 Extraction process inspection factor level table

[0045]

[0046] Test method: take the Chinese medicine composition 1 of the present invention and add 90% ethanol to extract twice according to the requirements of each test column number under the orthogonal test table 2...

Embodiment 3

[0054] Embodiment 3 Chinese medicine composition of the present invention is to the influence of spontaneously hypertensive rat (SHR) blood pressure and kidney

[0055] Experimental animals: 40 16-week-old male SHR rats, clean grade, screening criteria: body weight (200±15.0) g; systolic blood pressure (145±5) mmHg.

[0056] Method: 40 16-week-old male SHR rats were adaptively fed for one week, and then randomly divided into SHR control group, Chinese medicine composition 1 group of the present invention, Chinese medicine composition 2 groups of the present invention, and Chinese medicine composition 3 groups of the present invention, each 10 Only. All experimental animals were fed in a clean, well-ventilated environment with a temperature of 20°C-22°C, a humidity of 40%-70%, and 12 hours of light / darkness; the autoclaved litter was replaced once a week; free access to food, water, feed and Drinking water is sterilized by high temperature and high pressure. Administration ...

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Abstract

The invention provides a traditional Chinese medicine composition for treating hypertension. The traditional Chinese medicine composition is prepared from medicinal materials which are appropriately matched, can meet traditional Chinese medicine and modern medicine study theories, has a good antihypertensive effective, has an organ protection function and is low in toxic or side effect. The traditional Chinese medicine composition mainly contains 10-20 parts of rheum officinale, 10-20 parts of polygonum multiflorum, 15-30 parts of polygonum cuspidatum, 20-40 parts of astragalus membranaceus, 20-40 parts of angelica sinensis, 10-30 parts of uncaria rhynchophylla, 15-25 parts of polygonatum kingianum, 20-30 parts of spica prunellae, 3-8 parts of chrysanthemum, 10-20 parts of radix paeoniae alba, 15-40 parts of concha haliotidis, 15-30 parts of honeysuckle, 10-20 parts of plantain, 10-20 parts of hawthorn and 10-20 parts of motherwort.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating hypertension and a preparation method thereof. Background technique [0002] In today's society, with the improvement of people's living standards, the improvement of dietary structure and the acceleration of work and life rhythm, hypertension has become a common and frequently-occurring disease. With the development of population aging in our country, the number of patients with hypertension has reached 220 million. The serious complications of heart, brain and kidney damage have seriously threatened the life and health of the people in our country. The prevention and treatment of hypertension is imminent. [0003] The principle of modern medicine to treat hypertension is only antihypertensive treatment for hypertension, which cannot eliminate the internal causes of the occurrence and devel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P9/12A61K35/618
CPCA61K35/618A61K36/232A61K36/287A61K36/355A61K36/481A61K36/533A61K36/536A61K36/65A61K36/68A61K36/704A61K36/708A61K36/71A61K36/734A61K36/74A61K36/8969A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 冯恩平殷金龙
Owner JILIN ZIXIN PHARMA