Synthetic method of medicine intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine

A technique for the synthesis of dihydroxypyrimidine and its synthesis method, which is applied in the field of synthesis of pharmaceutical intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine, which can solve problems such as the synthesis method of unreported compounds, and achieve the synthesis method simple effect

Inactive Publication Date: 2017-03-22
WUXI QIANHAO BIOPHARMA
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Problems solved by technology

[0002] The synthesis method of 2-ethyl-5-chloro-4,6-dihydroxypyrimidine is the starting material for the synthesis of many drugs, especially the important intermediates of many hydroxypyrimidine compounds. At present, there is no report on the synthesis method of this compound in China

Method used

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Embodiment Construction

[0008] The synthetic method of pharmaceutical intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine of the present invention is specifically as follows:

[0009] Using 5-bromopyrimidine as a raw material, under the action of solvent diethyl ether and 2 atmospheres, at a temperature of 120°C-150°C, 2-ethyl-5-chloro-4 is produced successively through chlorine displacement reaction, ethylation and hydroxylation, Synthetic method of 6-dihydroxypyrimidine. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.

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Abstract

The invention relates to a synthetic method of a medicine intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine. The synthetic method is characterized in that 2-ethyl-5-chloro-4,6-dihydroxypyrimidine is prepared through successively carrying out a chlorine displacement reaction, an ethylating reaction and a hydroxylation reaction of 5-bromopyrimidine used as a raw material in a solvent ether at 120-150 DEG C under 2 atm. The synthetic method of the medicine intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine has the advantages of simplicity, high efficiency, safety in operation, and high practicality in concrete production, can meet the general reaction demands and can be applied to practical reactions.

Description

technical field [0001] The invention relates to a method for synthesizing a pharmaceutical intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine. Background technique [0002] The synthesis method of 2-ethyl-5-chloro-4,6-dihydroxypyrimidine is the starting material for the synthesis of many drugs, especially the important intermediate of many hydroxypyrimidine compounds. There is no report on the synthesis method of this compound in China. Contents of the invention [0003] The object of the present invention is to overcome the above-mentioned disadvantages and provide a simple, efficient and safe synthetic method for the pharmaceutical intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing pharmaceutical intermediate 2-ethyl-5-chloro-4,6-dihydroxypyrimidine, using 5-bromopyrimidine as raw material, under the action of solvent diethyl ether and 2 atmospheric pressure, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/553
CPCC07D239/553
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
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