Preparation method of natural biflavone i3, ii8-biapigenin and ridiculuflavone A

A biflavone, natural technology, applied in the preparation method of new compounds and the field of medicine, can solve the problems of limited activity research, scarce sources, etc., and achieve the effect of wide biological activity and simple purification method
CN106518827BActive Publication Date: 2018-09-14TIANJIN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN UNIV OF SCI & TECH
Publication Date
2018-09-14

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Abstract

The present invention belongs to the field of new compound preparation methods and medicine research, and particularly relates to a preparation method of natural biflavones such as I3,II8-Biapgienin and Ridiculuflavone A. According to the present invention, the two compounds such as I3,II8-Biapgienin and Ridiculuflavone A are firstly synthesized, wherein I3,II8-Biapgienin has good anti-depression activity, good anti-tumor activity, good anti-oxidation activity, good anti-inflammatory activity and good anti-liver injury activity, further has inhibition activity on estrogen receptors, benzodiazepine receptors and CYP, and has broad prospects in the fields of drug development and application.
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Description

technical field

[0001] The invention belongs to the field of novel compound preparation method and medicine, especially the preparation of natural biflavone compounds I3, II8-Biapigenin and Ridiculuflavone A. Background technique

[0002] I3, II8-Biapigenin is a biflavonoid compound extracted from Hypericum perforum L, which is also known as St. John's Wort in Europe and the United States. Hypericum perforatum is used in Germany The treatment of depression has a history of hundreds of years. It has been reported that I3, II8-Biapigenin has good antidepressant, antitumor, antioxidative, anti-inflammatory, and anti-liver damage activities, and also has effects on estrogen receptors and benzodiazepines. Body and CYP have inhibitory activity, and have broad prospects in drug development and application.

[0003] Ridiculuflavone A is a natural biflavone compound extracted from Aristolochia ridicula, a plant of the potato family. Due to the scarcity of its source, the research o...

Claims

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