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Conformal radiotherapy patch and its manufacturing method and use

A manufacturing method and conformal technology, applied in the medical and cosmetic fields, can solve problems such as uncountable radioactive dose, poor patient compliance, and inability of patients to persist

Active Publication Date: 2017-12-01
CHENGDU WEINING BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] The problems of these two kinds of applicators in the prior art are: one, the nuclide half-life is long, the risk of contamination is large, 90 The half-life of Sr is 28 years, and if it leaks, it will cause great pollution to the environment; second, it can only be used in hospitals, and patients' compliance is poor. 90 Sr / 90 Y and 32 Each course of P application requires 8-10 treatments, and many intractable diseases require 2-3 courses of treatment to be effective. Such a cumbersome and long treatment cycle makes most patients unable to persist; third, the radioactive dose cannot be counted, and doctors only Able to estimate time based on experience

Method used

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  • Conformal radiotherapy patch and its manufacturing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Disease Type: Skin Hemangioma

[0085] There were 83 cases of skin hemangioma, including 59 cases of simple capillary hemangioma, accounting for 72%; 7 cases of cavernous hemangioma, accounting for 8%; 17 cases of port wine stain and mixed hemangioma, accounting for 20%. There were 62 cases of round and oval lesions, and 21 cases of abnormal shape. According to the patient's condition and the radioactive dose calculation system, the nuclide of the conformal radiotherapy patch is P-32, the activity range is 0.37-200 MBq, and the material of the support is high-quality filter paper with an area of ​​0.1-50 cm 2 , the thickness is 0.1-2 mm, and the protection adopts lead rubber with a thickness of 0.1-2 mm. The warning device is common for sound warning and light warning.

[0086] The total radiation dose of the patients was 15-55 Gy. According to the changes of the condition, a total of 20 cases (25%) were treated again after 3-4 weeks.

[0087] Treatment effect: 75 cas...

Embodiment 2

[0089] Disease type: Keloid

[0090] There were 126 cases of keloids, 102 cases of lesions were round and oval, 10 cases were approximately square, and 14 cases were abnormal. According to the patient's condition and the radioactive dose calculation system, the nuclide of the conformal radiotherapy patch is Y-90, the activity range is 10-600MBq, and the material of the support is a water-absorbent resin film with an area of ​​1-180 cm 2 , the thickness is 0.1-3 mm, and the protection adopts copper-containing rubber with a thickness of 0.1-3 mm. The warning device is common for sound warning and vibration warning.

[0091] The total irradiation dose for patients is 30-100 Gy, and the cure rate of keloid is low in one treatment, and about 30% of patients need 2-4 treatments.

[0092] Treatment effect: 95 cases were cured, accounting for 76%; 21 cases were significantly improved, accounting for 17%; 11 cases were improved, accounting for 9%, the total effective rate was 100%.

Embodiment 3

[0094] Disease Type: Neurodermatitis

[0095] There were 289 cases of neurodermatitis, and 289 cases had round and oval lesions. According to the calculation of the patient's condition and the radioactive dose calculation system, the nuclide of the conformal radiotherapy patch is Re-188, the activity range is 30-740 MBq, the material of the support is high molecular polymer, and the area is 1-180 cm 2 , the thickness is 1-5 mm, the protection is made of aluminum rubber with a thickness of 1-5 mm, and the warning device is common for sound warning and light warning.

[0096] The total dose of radiation therapy for patients is 20-40 Gy.

[0097] Treatment effect: After 1-3 courses of treatment, the cure rate is 82%, the effective rate is 98%, and the recurrence rate is 12%. After the recurrence, the patient needs to undergo 1-3 courses of treatment again.

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Abstract

The invention relates to a conformal radiotherapy patch and a manufacturing method and application thereof. The conformal radiotherapy patch comprises a seal film, a support part, a protective material and a dosage monitoring and controlling device, wherein the support part is used for immobilizing radionuclides. The conformal radiotherapy patch is characterized in that the support part which immobilizes the radionuclides is sealed by the seal film and the protective material, the dosage monitoring and controlling device monitors and controls dosage of the radionuclides through pores of the protective material, a half-life period of the radionuclides is shorter than four days, and pure beta rays are adopted. Therefore, high compliance and conformality and short half-life period of the radionuclides are realized, continuous radiotherapy and precise monitoring and controlling are both achieved, and defects of existing radiopharmaceuticals in targeted continuous treatment and dosage control precision in treatment of skin diseases are improved.

Description

technical field [0001] The invention belongs to the field of medical treatment and cosmetology, and relates to a novel external radiotherapy product, which is mainly composed of radionuclides and related auxiliary equipment. In further detail, it relates to a conformal radiotherapy patch for treating various skin diseases and superficial tumors, its manufacturing method and application. Background technique [0002] Cutaneous hemangioma is a benign skin vascular lesion caused by congenital vascular dysplasia. It is the most common benign tumor in infants and young children. The incidence rate is 1%-2% in newborns, and as high as 12% after 1 year old. Hemangiomas were divided into four types: simple capillary hemangioma (strawberry hemangioma), port wine stain, cavernous hemangioma, and mixed hemangioma. It usually grows rapidly within 1 year, especially within half a year, and some can gradually degenerate within 5-7 years. However, some hemangiomas will not regress on the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M36/14A61K51/12A61P17/02A61P35/00A61K103/00
CPCA61K51/1279A61N5/1029A61N5/1048A61N2005/1092A61N2005/1094
Inventor 王铖锴韩东乔石峰
Owner CHENGDU WEINING BIOLOGICAL TECH