63 results about "Delivered radiation dose" patented technology

The invention discloses a method for reconstruction of a super-resolution coronary sagittal plane image of a lung 4D-CT image based on motion estimation. The method for reconstruction of the super-resolution coronary sagittal plane image of the lung 4D-CT image based on the motion estimation comprises the sequential steps of (1) reading data of the lung 4D-CT image which is formed by a plurality of lung 3D images, wherein the phase positions of the lung 3D images are different; (2) extracting coronary sagittal plane images, corresponding to the same position of the lung, from all the phase positions according to the data of the lung 4D-CT image; (3) estimating motion vector fields between the lung coronary sagittal plane images with different frames based on the full search block matching algorithm; (4) reconstructing the super-resolution lung 4D-CT coronary sagittal plane image by means of the iteration back projection method and based on the motion vector fields obtained in the step (3). According to the method for reconstruction of the super-resolution coronary sagittal plane image of the lung 4D-CT image, the resolution ratio of the reconstructed super-resolution lung 4D-CT coronary sagittal plane image obtained with the method is improved obviously, the brightness and definition of blood vessels and peripheral tissue in the lung parenchyma are improved obviously in a partial enlarged image, the limitation of low resolution caused by the collection time and radiological dose is eliminated, and accurate radiotherapy of lung cancer can be effectively guided.

The invention relates to a simulation and planning system for intraoperative radiation therapy and to a method allowing said system to be used for treatment studies, simulation, planning, training and recording, which system generally comprises a central processing unit or computer (1) for management and control and software-based communication with the rest of the devices and the user; one or several monitors or screens (2) for displaying images and peripherals responsible for gathering data relating to the actions performed by said user, a deformation simulation module for the virtual simulation of the deformation produced in the organs and tissues during the process; algorithms for instantly calculating the radiation dose applied during the radiation therapy treatment simulation and means for recording all the activities carried out and generating a full dosimetry report.

The invention relates to a conjugated carbon-iodine polymer, preparation thereof and application of the conjugated carbon-iodine polymer in preparation of a positioning marker, and belongs to the technical field of imaging markers. According to the brand-new imaging marker based on the conjugated carbon-iodine polymer disclosed by the invention, due to the conjugated structure, the polymer has very strong absorption in a visible light region, and the iodine content up to 84.1% corresponds to the superstrong imaging capability of the polymer. In the tumor operation process, based on double guidance of polymer image marking and naked eye observation, the marking can better assist in determining the cutting edge of the tumor, so that accurate cutting of the tumor is achieved, and damage to surrounding normal tissue is reduced as much as possible. In the tumor cyber knife treatment process, the polymer can replace a clinical gold mark to provide ray marking guidance, the ray imaging quality and more accurate radiation dose distribution are improved due to no metal artifacts, the relative stability of the marking position is improved due to good biocompatibility, and the radiotherapy side effect can be further reduced.

The invention discloses an edentulous jaw oral implant guide plate retaining device, an implant guide plate, a preparation method and a fixation method thereof, and belongs to the technical field of oral implants. Through the cooperation between the retention pin and the retention cap, the position of the retention pin in the oral cavity can be re-engraved in the mold through the retention cap when the mold is taken out, according to the position of the retention pin in the model, the position of the one-way retention hole of the positioning retention pin is determined on the implant guide plate, The implant guide plate is positioned and fixed through a one-way retention hole and a retention nail after the implant guide plate is put into the oral cavity, thereby playing the role of fixingthe implant guide plate, ensuring that the position of the implant guide plate in place during the operation is consistent with the position designed before the operation, reducing the error caused bythe position deviation of the implant guide plate, and improving the repair effect. Compared with the traditional edentulous patient, the invention reduces the steps of photographing the CBCT in theinitial diagnosis, and reduces the radiation dose accepted by the patient. Retention devices are less invasive, less costly, and more easily accepted by the majority of patients.

A radiotherapy treatment verification and quality assurance method may include receiving at least one set of first medical images of at least a portion of a patient. A three-dimensional model of the portion of the patient may be created based on the at least one set of first medical images. At least one dosimeter may be inserted into at least a portion of the model. The dosimeter is configured to measure exposure to radiation. The model may be irradiated in accordance with a radiotherapy treatment plan created by a treatment planning system. A readout of the model may be taken or performed to measure in three-dimensions a delivered radiation doses distribution.

The invention relates to a radiation parameter determination method and device, electronic equipment and a storage medium. The method comprises the steps of performing segmentation processing on a to-be-processed image through a segmentation network to obtain a first contour of a target area and a second contour of a protection area; inputting the to-be-processed image, the first contour, the second contour and a preset radiation dose into a dose array network to obtain a dose array; inputting the dose array, the first contour and the second contour into a radiation parameter network to obtaininitial radiation parameters; and determining a target radiation parameter according to the initial radiation parameter and a preset radiation dose. According to the radiation parameter determinationmethod provided by the embodiment of the invention, a target area and a protection area in the image are automatically segmented through the segmentation network, and errors of manual intervention are reduced. The initial radiation parameters of the medical instrument are determined through the dose array network and the radiation parameter network, so that the target radiation parameters are determined, the process of determining the radiation parameters can be automatically realized, and the working efficiency and the accuracy of the scheme are improved.

A method for fiducial-less real-time motion tracking of abdominal tumors based on the correlation between the patient's breathing pattern and the diaphragm/lung border during treatment delivery. This invention utilizes an edge detection technique to delineate the diaphragm/lung border on radiographic images in order to calculate or determine tumor locations in the abdomen. The position of the diaphragm/lung border is synchronized with the breathing pattern obtained from continuous optical monitoring of a patient's respiratory cycle. The real-time optical breathing pattern obtained from monitoring is used to determine or calculate the position of the diaphragm/lung border during treatment delivery. The position of the diaphragm/lung border is then used to determine the tumor location in real-time. The target tumor coordinates generated through this process are used by the treatment delivery system to adjust the radiation beam geometry of the treatment delivery system to follow the tumor in real-time and accurately deliver radiation dose.

The invention discloses a lung cancer resisting cell strain for radiotherapy, and a construction method and an application of the cell strain, and particularly discloses an application of the cell strain in preparation of the equal-difference dose gradient radiation human lung cancer surviving or resisting cell model. The lung cancer cell resisting line for radiotherapy is selected from three radiation resistant cell lines derived from a human lung cancer cell line A549, the strain is named as a human lung cancer cell radioactive ray resistant strain A549-20F, A549-30F and A549-40F respectively, and the preservation numbers of the strains are CGMCC No. 18161, CGMCC No. 18163 and CGMCC No. 18162 respectively. The cell model provided by the invention is closer to a clinical dose segmentationmodel, the radiation effect is more closely observed and researched dynamically according to the radiation dose in clinical practice; a series of continuous specific changes caused by progressive increase of the radiotherapy dosage in a lung cancer patient can be better simulated, key biomarkers for promoting lung cancer radiation survival/resistance can be found, a radiation resistance generation mechanism can be clarified, and the model has important significance for clinically optimizing a radiotherapy scheme and realizing accurate radiotherapy.

The invention discloses a radiotherapy dose optimization method and device. The method comprises the following steps: acquiring a first reference dose of a target voxel set and an irradiation dose of the target voxel set; optimizing the irradiation dose of the target voxel set according to the first reference dose and a preset target function; wherein the value of the target function is in positive correlation with the difference between the irradiation dose of the target voxel set and the first reference dose; and determining that the irradiation dose of the target voxel set reaches the optimized target dose under the condition that the target function reaches a set condition. The technical problem of low radiation dose optimization efficiency caused by excessive dependence on manual debugging is solved.

The invention provides a thin film transistor array substrate, a pixel circuit, an X-ray detector and a driving method thereof and relates to the technical field of photoelectricity. The thin film transistor array substrate comprises scanning lines, reading scanning lines, data lines and bias lines, wherein the scanning lines and the reading scanning lines are horizontally arranged, and the data lines and the bias lines are vertically arranged. The plurality of pixel units are defined by the scanning lines and the data lines in a crossed manner; each pixel unit comprises a photoconductive thinfilm transistor positioned in the photoconductive region and a reading thin film transistor positioned at the reading end. The photoconductive effect of the aSi thin film transistor is utilized to integrate the photocurrent and control the magnification times, so that the signal amplification in the pixel is realized, and the precise control of the magnification times can be realized while the radiation dose is reduced; meanwhile, the pixel structure and the process structure are simplified.

The invention discloses a triazolopyrimidine compound, a preparation method and application thereof. The triazolopyrimidine compound is an mTOR inhibitor with a novel structure, the lead compound hasa new compound skeleton found by using a virtual screening and pharmacophore method, and targeted design is carried out according to different PI3K and mTOR protein structures. Therefore, the lead compound has the characteristics of high activity and high selectivity. Moreover, the compound is creatively used as a radiosensitizer for cancer treatment, so that the sensitivity of cancer cells to radiotherapy can be improved, the radiation dose in radiotherapy is greatly reduced, the side effect is reduced, and the radiotherapy effect is improved.

The invention provides a method for dynamically adjusting the radioactive angle and dosage according to the movement of a tumor. According to the method, the moving position and spreading area of a dynamic tumor are precisely predicted and tracked, and the deflection of a radioactive angle is adjusted in time, and the radioactive dosage of a treatment target can be accurately controlled. The method comprises the following steps: (1) extracting the edge of a target tumor; (2) performing area related matching; (3) performing time grid clustering; (4) predicting the moving tumor position; and (5)adjusting the radioactive angle and dosage.

The invention relates to a sensitizer for radiotherapy and a preparation method and application of the sensitizer, belongs to the field of nano material chemistry and biochemistry, and solves the problems that the existing radiotherapy sensitizer cannot improve the hypoxic state in a tumor microenvironment, is insensitive to radiotherapy, large in dosage of a radiation agent and large in damage tonormal tissues. The molecular formula of the sensitizer for radiotherapy is BiO2-x, the molecular structure has oxygen vacancy, and the preparation raw material of the sensitizer comprises hydroxideof alkali metal and bismuthate. The preparation method of the sensitizer comprises the following steps: dissolving the hydroxide of alkali metal and the bismuthate, and stirring to obtain a solution;transferring the solution into a reaction container, heating, and reacting for a period of time; the BiO2-x provided by the invention can be used as the sensitizer to be applied to radiotherapy sensitization of tumors, and has a very good inhibition effect on tumors under a relatively low radiation dose.

The invention discloses a cone beam CT and image fusion combined cervical vertebra in-vivo three-dimensional motion analysis method. The method comprises the following steps of S1, enabling a cone beam CT machine to shoot images of different cervical vertebra function positions; S2, importing to carry out image segmentation and 3D modeling; S3, for the 3D cervical vertebra model at the neutral position, determining a local coordinate system according to the anatomical orientation of the human body; S4, performing image fusion and recording spatial position parameter change on each segment of cervical vertebra model at different functional positions relative to the neutral position; S5, performing threshold judgment on the precision of image fusion to determine whether the image fusion is successful or not; and S6, further calculating the spatial position parameter change between different sections to obtain the relative change of the two sections, and the invention relates to the technical field of CT influence. According to the invention, the problem of unclear imaging caused by conventional X-ray fluoroscopy shooting is solved; nuclear magnetic resonance (MRI) or computed tomography (CT) is adopted, so that dynamic motion abnormity cannot be seen; MRI is long in scanning time and inconvenient in 3D modeling; and CT also has the problems of large radiation dose and the like.

The invention relates to the technical field of interventional radiology arterial embolism, and discloses a radioembolism dose and injection position evaluation method based on fluid dynamics. Medical imaging images are acquired and preprocessed, and an artery tree is subjected to recognition and three-dimensional reconstruction by using the trained deep learning model and an accurate modeling method; segmenting and naming the reconstructed blood vessel; obtaining the flow of each blood vessel outlet of the embolism part based on fluid dynamics, and calculating embolism efficiency and organ injury conditions during injection at different embolism positions based on the flow of each blood vessel outlet of the embolism part; the method comprises the following steps: calculating the microsphere radiation quantity of each blood vessel outlet based on a flow ratio, then analyzing the radiation dose and distribution of the microspheres by using a statistical simulation method, drawing a radiation dose distribution three-dimensional cloud chart, and evaluating the damage degree of organs based on the radiation dose of the microspheres to ensure the treatment effect on tumors.

The invention discloses a radiation dose distribution prediction method and device based on a CT image, and the method comprises the steps: processing a to-be-predicted CT image through a convolutional neural network, and obtaining a first feature map and a second feature map which are corresponding to the to-be-predicted CT image and have different resolutions, and a first initial differential field and a second initial differential field; further predicting the feature map and the initial differential field through a decoder stream to obtain a first differential field and a second differential field, and continuously sampling a prior image shape through a continuous differential field, thereby deforming a prior with correct topological features through the continuous differential field to maintain topology; as the first differential field and the second differential field are differential homomorphic fields which are continuous deformation fields causing one-to-one mapping, the derivatives of the first differential field and the second differential field are reversible, and a positive Jacobian can be obtained, so that clear mapping between a prior shape and predicted image coordinates is given in dose registration, 100% topology maintenance is achieved, and the accuracy of dose registration is improved. And the accuracy of radiation dose distribution prediction is improved.

The invention provides a system and method for verifying a primary radioactive dose distribution curve and a storage medium. The system and method for verifying a primary dose distribution curve generated by a radiation machine by using cloud-based services are discussed. An illustrative system may comprise: cloud, which is used for providing the cloud-based services; and a user interface, which is used for enabling a plurality of occupants to access the cloud-based services. File service can be used for extracting image information and information on the radiation machine from a DICOM file of a sufferer. Dose engine service can be used for determining a secondary radioactive dose distribution curve through applying a dose algorithm to the image information and the information on the radiation machine. The applied dose algorithm can be different from that of the radiation machine for generating the primary dose distribution curve. Dose evaluating service can be used for indicating and verifying the accuracy of the primary dose distribution curve based on consistency between the primary dose distribution curve and a secondary dose distribution curve by using the secondary radioactive dose distribution curve.