The radioactive nanometer coating compound rack and its preparation method

A composite stent and radioactive technology, which is applied in the field of medical devices, can solve the problem that the combination of radioactive isotopes and metal mesh stents is not enough to achieve the treatment of malignant tumors, and achieve the effects of easy dose control, improved quality of life, and prolonged life.

Inactive Publication Date: 2007-04-11
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the radioactive metal stents currently used clinically are mainly used for the prevention of restenosis after expansion of benign vascular lesions, and there are still many problems in the prevention and treatment of lumen narrowing caused by malignant tumors: (1) radioisotopes and metal mesh The combined amount of stent-shaped stent is not enough to achieve the the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0013] Example 1:

[0014] Preparation of Esophagus Composite with Radioactive Nanocoating 125 I bracket

[0015] The medical esophageal metal stent (30×10 mm) was purchased from Changzhou Intellectually Invasive Medical Instrument Co., Ltd.

[0016] Weigh 16 mg of purified and open-treated carbon nanotubes (CNTs), put them in a measuring tube, seal with a rubber stopper, and vacuumize the measuring tube with a vacuum pump. Take 5 μL of a certain activity ( 125 I) NaI solution was added to 1 mL of deionized water and shaken. Then use a syringe to inject this solution into a vacuum-evacuated airtight measuring tube, ultrasonically disperse it, and let it stand overnight. For injection ( 125 1) The CNTs of NaI are washed several times with deionized water to remove the ( 125 I) NaI, after each wash and centrifugation, use a NaI(T1) well-type scintillation gamma counter to measure the radioactive counting rates of the supernatant and CNTs, respectively. will be filled with...

Example Embodiment

[0022] Example 2:

[0023] Tracheal Composite Fabricated with Radioactive Nanocoating 125 I bracket

[0024] Medical endotracheal metal stents were purchased from Changzhou Intellectually Invasive Medical Devices Co., Ltd.

[0025] The preparation method of the nano-coating film is the same as in Example 1. The specification of the metal inner stent for the medical airway is 10×5 mm, and the radiation dose of the stent is 900 microcui; the radiation dose error is 10-15% (related to the size of the stent).

[0026] In vitro experiments: 125 The leakage rate of coating I soaked in saline for 35 days was 0.2%.

[0027] The above-mentioned bracket is bent at 180 degrees, and under a microscope magnified 100 times, there is no crack or shedding.

[0028] Anti-compression test: When the above-mentioned stent is compressed 5 times, the membrane is magnified 100 times under a microscope without cracks, bending or falling off.

[0029] The thickness of the stent coating film is no...

Example Embodiment

[0030] Example 3:

[0031] Animal Experiments of Radioactive Nano-coated Composite Stent

[0032] 1) Esophageal composite of radioactive nanocoating 125 Animal experiments of I bracket:

[0033] Divide the rabbits into three groups: Group A: 125 I dose 300 microci (μCi) 4 pieces; B group: 125 I dose 900PCi 4 pieces; Group C: 4 blank covered stents. Animals: male or female, under the supervision of digital subtraction angiography (DSA) after anesthesia, a 5F Corbra catheter was selectively inserted into the esophagus, a guide wire was inserted along the catheter, and the stent was released after positioning under fluoroscopy. The animals were fed with specially-assigned feed, and the animals were sacrificed on day 1, day 7, and day 14 after operation. Detection: Three-dimensional DSA reconstruction and esophagography; CT scanning of esophageal stents at the end of the operation and before sacrificing the animals; pathological examination.

[0034] The results showed that:...

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Abstract

The invention relates to medical equipment and technology, especially the radioactive nano-coated steadier for the treatment of esophageal, airway and biliary tumors and its preparation method. The radioactive metal steadier applied in clinic at present are mainly used for the prevention of vascular restenosis after benign expansions, in the prevention and cure against the narrow cavity diseases caused by malignant tumor, there are still many problems. The invention develops radioactive nano-coated compound steadier by advanced nuclear and nano-technology technology. The original medical steadier was coated with a layer containing the isotope 125I nano composite film, with 300 to 900 radiation dose, less than 300 nm coating thickness. The invention not only has a supporting effect, but also has fistula prevention and radiation therapy effect. In a fairly long period of time to maintain the vascular flow, which not only improves the quality of life of patients but also prolong the patient's life.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a radioactive nano-coated composite stent for treating esophagus, airway and biliary tract tumors and a preparation method thereof. Background technique [0002] At present, the treatment of advanced malignant tumors mainly adopts comprehensive treatment methods, including surgery, systemic chemotherapy, internal radiotherapy, external radiotherapy, laser and supportive treatment. It has received good results in malignant stenosis of the lumen and has been widely used clinically. In recent years, stent technology combined with intracavitary brachytherapy has effectively alleviated the obstructive symptoms of patients with malignant tumors. The main methods are: (1) catheter-based high-dose afterload source irradiation; (2) liquid-filled bulb Radiation from capsule source; (3) direct implantation of radioactive vascular stent. [0003] However, the radioactive metal sten...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/16
Inventor 董生袁正吴胜伟李文新
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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