Sensitizer for radiotherapy and application thereof
A technology of sensitizer and surfactant, which is applied in the fields of nanomaterial chemistry and biochemistry, can solve the problems that radiotherapy sensitizers cannot improve the hypoxic state of the tumor microenvironment, cause large damage to normal tissues, and consume a large amount of radiation agents. Easy to implement and popularize, reduce dosage, good inhibitory effect
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Embodiment 1
[0051] A specific embodiment of the present invention discloses a sensitizer for radiotherapy, and the molecular formula of the sensitizer is BiO 2-x , the molecular structure has oxygen defects, and the raw materials for the preparation of sensitizers include alkali metal hydroxides and bismuthates.
[0052]Compared with the prior art, on the one hand, the molecular structure of the sensitizer provided in this embodiment has oxygen defects, and the bismuth oxide containing oxygen defects can efficiently catalyze hydrogen peroxide to generate oxygen, and has an effect similar to catalase, The oxygen generated by catalysis can improve tumor hypoxia and improve the sensitivity of tumor radiotherapy, thereby reducing the dosage of radiotherapy agents, thereby reducing the damage to normal tissues, and achieving a very good inhibitory effect on tumors at lower radiation doses. On the other hand, by selecting metal bismuth with a specific atomic number, it has a very good absorptio...
Embodiment 2
[0058] Another embodiment of the present invention discloses a method for preparing a sensitizer, which is used to prepare the sensitizer for radiotherapy of Example 1, comprising the following steps:
[0059] Step 1: Disperse 0.8-1.2 g of alkali metal hydroxide and 1 g of bismuth salt in deionized water, and stir to obtain a solution;
[0060] Step 2: transfer the solution to the reaction vessel, heat to 160~200℃, and react for 4~10h;
[0061] Step 3: Cool to room temperature, wash with deionized water, and dry at 60-100°C for 2-8 hours to obtain BiO 2-x .
[0062] It should be noted that in step 2, the reaction time should not be too long, because if the time is too long, many by-products, such as other oxidized products of bismuth, will be generated, which will affect the sensitivity to tumor radiotherapy; while the reaction time is too short, it will lead to reaction incomplete. The reaction time is controlled to be 4 to 10h, and the reaction temperature is controlled t...
Embodiment 3
[0070] (1) Take 0.5g NaOH and 1g NaBiO 3 Disperse in 15mL deionized water, stir for 2 hours to disperse evenly;
[0071] (2) Transfer the well-stirred solution to a 50 mL hydrothermal kettle, and react at 160° C. for 10 hours. After cooling to room temperature, wash with deionized water for 5 times and bake at 60°C for 8 hours;
[0072] (3) 400mg BiO 2-x Dissolve in 16mL of water and 16mL of ethanol, then add 16μL of Tween-20 (Tween-20) to obtain a mixed solution;
[0073] (4) ultrasonication (300W) of the mixed solution in an ultrasonic tank for 30 minutes;
[0074] (5) use an ultrasonic cell disruptor to break for 12 hours, take out after the breaking is completed, cover with a parafilm and let stand for one night, remove the material precipitated at the bottom, and take the uniformly dispersed solution on the upper layer;
[0075] (6) Centrifuge at 12,000 rpm for 5 minutes, continue to wash with deionized water three times, and then freeze-dry it for later use.
[0076...
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