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Polymeric polyglycolide-polylactide radioactive seed source thin-layer tablet and it spreparing method

A technology of polyglycolide and lactide, which is applied in the direction of radioactive carriers, can solve the problems of few clinical application reports, and achieve good antibacterial and anti-inflammatory effects, good biocompatibility, and practical product effects

Inactive Publication Date: 2005-12-21
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In recent years, the United States has developed polyglycolide-lactide (PGLA) as a carrier in the United States. 125 I seed source thin-layer tablets are used for tumor treatment, but due to the problems of biomaterial degradation and absorption speed control, manufacturing technology, etc., there are few clinical application reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Dry the absorbable polymer polyglycolide-lactide (PGLA) (the ratio of GA to LA is 90:10) in an oven at 100°C for 24 hours, The melt with a temperature of 210°C is produced inside, sprayed out from the spinneret by a metering pump, and solidified in the filament chamber. The medium in the filament chamber is air, and the temperature is room temperature; the prepared primary fiber is wound on the bobbin Above, the winding speed is 200 m / min; the as-spun fiber on the bobbin is subjected to two-stage stretching, the first-stage stretching temperature is 70°C, the second-stage stretching temperature is 80°C, and the total draw ratio is 5.0 times; followed by heat setting in an oven at a temperature of 100°C.

Embodiment 2

[0025] Dry the absorbable polymer polyglycolide-lactide (PGLA) (the ratio of GA to LA is 90:10) in an oven at 100°C for 24 hours, The melt is produced at a temperature of 215°C, sprayed out from the spinneret by a metering pump, and solidified in the filament chamber. The medium in the filament chamber is air, and the temperature is room temperature; the prepared primary fiber is wound on the bobbin Above, the winding speed is 200 m / min; the as-spun fiber on the bobbin is subjected to two-stage stretching, the first-stage stretching temperature is 80°C, the second-stage stretching temperature is 90°C, and the total draw ratio is 3.5 times; followed by heat setting in an oven at a temperature of 100°C.

Embodiment 3

[0027]Dry the absorbable polymer polyglycolide-lactide (PGLA) (the ratio of GA to LA is 75:25) in an oven at 100°C for 24 hours, The melt with a temperature of 220°C is produced inside, sprayed out from the spinneret by a metering pump, and solidified in the filament chamber. The medium in the filament chamber is air, and the temperature is room temperature; the prepared primary fiber is wound on the bobbin Above, the winding speed is 250 m / min; the as-spun fiber on the bobbin is subjected to two-stage stretching, the first-stage stretching temperature is 75°C, the second-stage stretching temperature is 85°C, and the total draw ratio is 6.5 times; followed by heat setting in an oven at a temperature of 100°C.

[0028] Preparation of polymer polyglycolide-lactide radioactive seed source thin-layer sheet

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Abstract

The present invention discloses a high-molecular polyglycolide-lactide radioactive seed source thin-layer sheet and its preparation method. The yarn made up by using high-molecular polyglycolide-lactide can be woven into gauze fabric, on the fabric the radioactive seed source is placed, and two surfaces of said fabric are respectively coated with chitosan layer whose thickness is 0.25-0.35mm. Said invention adopts high-molecular medical material chitosan to make coating and after-processing, so that the PGLA degradation can be implemented under the controllable state, and the new type collating layer PGLA with special biological degradability can be used as carrier and thin-layer support, and can be used for curing tumor bed residue, and can ensure uniformity of radio logical dose distribution.

Description

1. Technical field [0001] The present invention relates to a polymer polyglycolide-lactide radioactive seed source thin-layer sheet and its preparation method, more particularly to a polymer coated with chitosan solution and has slow-release function Polyglycolide-lactide radioactive seed source thin-layer sheet and its preparation method. 2. Background technology [0002] The permanent implantation of radioactive seeds (or microradiation sources) between tissues is a new internal radiotherapy technology developed in recent years. The radioactive seed source is a short rod-shaped solid radioactive source made of low-energy radioactive isotopes sealed with a titanium alloy shell. Currently, there are iodine-125 ( 125 I), palladium-103 ( 103 Pd) and gold-198 ( 198 Au) radioactive seed source, etc., its physical characteristics and treatment principles are similar, among which 125 The clinical application of I seed source is the most extensive. [0003] In recent years, 1...

Claims

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Application Information

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IPC IPC(8): A61K51/02
Inventor 陈红红郯志清程文英王文祖罗伟华杨庆
Owner DONGHUA UNIV
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