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Gastric antiulcer sustained-release dropping pill for treating gastric and duodenal bulbar ulcers and preparation method thereof

A slow-release dropping pill, duodenum technology, applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pill delivery, etc., to achieve suitable viscosity, improve in vivo bioavailability, easy to disperse Effect

Active Publication Date: 2017-06-13
惠州市九惠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] How to prepare the active ingredient Anweike in licorice into sustained-release dripping pills, and apply it to the treatment of gastric ulcer and duodenal ulcer, so as to achieve delayed drug release and improve drug bioavailability, is a comparatively difficult task in this field. A new research topic, which is rarely mentioned in the existing technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method for Anweiyang sustained-release dropping pills for treating gastric and duodenal ulcers, comprising the following steps:

[0035](1) Precisely weigh the hydrophobic matrix, hydrophilic matrix and natural excipient matrix according to the designed ratio, fully melt and mix them under heating conditions, and then add licorice flavonoid fine powder and dripping pill matrix according to the ratio of licorice flavonoid fine powder powder, continue to stir continuously for 40 minutes under heating conditions, so that the dropping pill matrix and the fine powder of licorice flavonoids are fully mixed to obtain a feed liquid;

[0036] (2) Take the dropper and preheat the dropper so that the temperature of the dropper is equal to the temperature of the liquid;

[0037] (3) Use a dropper to absorb the material liquid, control the dropping speed and distance, quickly drop the material liquid into the coolant, and let it stand to condense;

[0038] (4) Collect...

Embodiment 2

[0050] According to the optimal prescription ratio of the Anweiyang sustained-release dripping pills of Example 1: the weight ratio of the drug licorice flavonoids to the dripping pill matrix is ​​1:6, and the water-insoluble matrix stearic acid (hydrophobic matrix) in the dripping pill matrix is ​​mixed with water-soluble The weight ratio of the soluble matrix (hydrophilic matrix and natural excipient matrix) is 1:6.2; in the water-soluble matrix, the weight ratio of the hydrophilic matrix PEG6000 is 30%, and the total weight ratio of the natural excipient matrix xylitol and gum arabic The proportion is 70%; and the weight ratio of xylitol and gum arabic in the natural excipient matrix is ​​10:1; and the best preparation process conditions: simethicone is the coolant, the temperature range of the feed liquid is 96°C, the dropping The speed was controlled at 20-30 drops / min, the drop distance range was 5cm, and the condensation temperature was 16°C. Three batches of Anweiyang S...

Embodiment 3

[0061] Three batches of Anweiyang Sustained-release Dropping Pills prepared in Example 2 were taken for in vitro release test. The release test method uses 1.5% sodium lauryl sulfate solution as the release medium, and the volume of the medium is 750mL. It is injected into each dissolution cup, and the temperature of the dissolution tester is adjusted to 37±0.5°C. The temperature is kept at 37±0.5°C, the rotation speed is 100r / min, and the release time is set at 12h. The blank sustained-release dropping pills were used as the control, and the ordinary PEG dropping pills were used as the comparison. Take three batches of Anweiyang sustained-release dripping pills 160902-1, 160902-2, and 160902-3, each with a total weight of 0.276g, 0.265g, and 0.252g, and put them into three dissolution cups, and take the blank slow-release drops The number of pellets is 3, with a total weight of 0.244g, which are placed in a dissolution vessel as a blank control. Take 3 ordinary PEG dripping...

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PUM

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Abstract

The invention relates to a gastric antiulcer sustained-release dropping pill for treating gastric and duodenal bulbar ulcers and a preparation method thereof. In the gastric antiulcer sustained-release dropping pill, a ratio of a fine licoflavone powder to a dripping pill substrate is 1 to (5-7). The dripping pill substrate comprises a hydrophobic substrate, a hydrophilic substrate and a natural auxiliary material substrate, and a ratio of the hydrophobic substrate to the hydrophilic substrate and the natural auxiliary material substrate is 1 to 1.86 to 4.34. The fine licoflavone powder is fine powder sifted through 100 meshes. The gastric antiulcer sustained-release dropping pills prepared by the preparation method of the gastric antiulcer sustained-release dropping pill for treating gastric and duodenal bulbar ulcers in the invention are good in formability and unique in pill weight. The bioavailability of the licoflavone can be increased; the number of times of taking and occurring side effects can be reduced, and the medicine compliance of a patient can be enhanced.

Description

technical field [0001] The invention relates to the technical field of therapeutic pharmaceutical preparations, in particular to an Anweiyang sustained-release dropping pill for treating gastric and duodenal ulcers and a preparation method thereof. Background technique [0002] With the improvement of our country's national economic level, people's dietary structure and lifestyle have undergone tremendous changes, and work pressure has also increased day by day. Irregular diet or preference for irritating tastes, staying up late, drinking, and other bad eating habits often occur. And these factors all can cause chronic gastritis and peptic ulcer disease, and the sick crowd is increasing day by day. Peptic ulcer is a common digestive tract disease that can occur in the esophagus, stomach or duodenum. It is most common in gastric ulcer and duodenal ulcer. Therefore, the so-called peptic ulcer generally refers to gastric ulcer and duodenal ulcer. Duodenal ulcer. [0003] Lico...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K9/20A61K47/12A61K47/26A61K47/36A61K47/10A61K47/34A61P1/04
CPCA61K9/0002A61K9/2013A61K9/2018A61K9/2031A61K9/2036A61K9/205A61K36/484
Inventor 刘强黄辉球
Owner 惠州市九惠药业有限公司
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