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Application of eucheuma polypeptide in prevention and treatment of pulmonary fibrosis

A technology of pulmonary fibrosis and Eucheuma, which is applied in the application field of Eucheuma polypeptide to prevent and treat pulmonary fibrosis, achieving the effect of significantly preventing and controlling pulmonary fibrosis and inhibiting the formation of pulmonary fibrosis

Active Publication Date: 2017-07-04
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant research on the prevention and treatment of pulmonary fibrosis by the polypeptide components of Eucheuma at home and abroad, and there is no report on the use of the polypeptide components of Eucheuma as a drug or health care product for the prevention and treatment of pulmonary fibrosis

Method used

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  • Application of eucheuma polypeptide in prevention and treatment of pulmonary fibrosis
  • Application of eucheuma polypeptide in prevention and treatment of pulmonary fibrosis
  • Application of eucheuma polypeptide in prevention and treatment of pulmonary fibrosis

Examples

Experimental program
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Effect test

Embodiment 1

[0040] The preparation of embodiment 1 Eucheuma polypeptide

[0041] 1. Preparation of Eucheuma polypeptide

[0042] Take 1 kg of Eucheuma pulveris, homogenate with 10L 20mmol / L HCl solution to prepare a crude liquid, if the solution is thick, add potassium chloride to a concentration of 1.5%; centrifuge the obtained crude liquid at 8000 rpm for 15 minutes, Collect the supernatant, filter the supernatant with three layers of gauze, and separate with dextran G-50 (Sephadex G-50) (the column height is 30 cm, the inner diameter width is 2.0 cm, and the height of the upper sample is 5-10% of the column height) . After equilibrium, elute with 20mmol / L HCl solution at a flow rate of 1.0mL / min, there are two groups of elution peaks, collect the second group of eluted products, adjust the pH of the solution to pH 6.0-7.0, and centrifuge at 10,000 rpm for 15 minutes , and the supernatant was freeze-dried to obtain the desired extract.

[0043] 2. It is confirmed by sodium dodecyl su...

Embodiment 2

[0044] Embodiment 2 prevents and treats pulmonary fibrosis experiment

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Abstract

The invention discloses an application of eucheuma polypeptide in the preparation of drugs or health products for the prevention and treatment of pulmonary fibrosis. The eucheuma polypeptide can be used to prepare drugs or health products for the prevention and treatment of pulmonary fibrosis; can be used to modify the precursor of drugs for the prevention and treatment of pulmonary fibrosis; and can be co-used with drugs for treating pulmonary fibrosis to treat pulmonary fibrosis. The eucheuma polypeptide is obtained by extracting and purifying eucheuma, can prominently inhibit the formation of pulmonary fibrosis, has a good effect on preventing and treating pulmonary fibrosis, and has an important application value in the prevention and treatment of pulmonary fibrosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of Eucheuma polypeptide in preventing and treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a common complication of the respiratory system. In recent years, the morbidity and mortality have been on the rise, posing a great threat to human health. [0003] Based on the "Evidence-Based Guidelines for the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis" jointly developed by the American Thoracic Society (ATS), the European Respiratory Society (ERS), the Japanese Respiratory Society (JRS) and the Latin American Thoracic Society (ALAT), it is pointed out that some drugs It has a potential effect on IPF patients. For patients with a strong desire for medication, they can choose from the following four treatment options: (1) N-acetylcysteine ​​+ azathioprine + prednisone; (2) N-acetylcysteine (3) anticoa...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61K36/04A61P11/00A23L33/18
CPCA23V2002/00A61K36/04A61K38/02A61K2236/333A61K2236/55A23V2200/314A23V2250/55A23V2250/202
Inventor 张海涛余华军伍俊
Owner GUANGDONG MEDICAL UNIV
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