Synthetic polypeptide for enhancing CIK cell killing sensitivity of hepatoma cells and biological product thereof

Abstract

The invention discloses synthetic polypeptide for enhancing CIK cell killing sensitivity of hepatoma cells and a biological product thereof. The synthetic polypeptide is polypeptide containing the amino acid sequence as shown in the formula (III): ETLGQPDAK(Xa)PCFQEDPMA(Xb)GTDCMELGIWN(III), wherein Xa and Xb are selected from M, Y, L, V, W or E. The synthetic polypeptide provided by the invention can effectively enhance CIK cell killing sensitivity of hepatoma cells, and can be made into a pharmaceutically-acceptable biological product. According to the invention, an excellent immunotherapy effect can be achieved with less use amount of CIK cells.

Description

technical field [0001] The invention belongs to the field of polypeptides, and relates to the application of polypeptides in cellular immunotherapy, in particular to artificial polypeptides and biological products for enhancing the killing sensitivity of liver cancer cells to CIK cells. Background technique [0002] Primary liver cancer (hereinafter referred to as liver cancer) is one of the most common malignant tumors in the world, with about 630,000 new cases every year, and the incidence rate has been on the rise in recent years. The disease course of liver cancer patients is short, and it is difficult to detect early clinically. When diagnosed, the disease is often in the middle or late stage, and the fatality rate is high. At present, the treatment of liver cancer is mainly based on surgical resection, liver transplantation, local ablation, chemotherapeutic embolization and other local and regional treatments, molecular targeted therapy, etc., but the therapeutic effec...

AI Technical Summary

Problems solved by technology

The disease course of patients with liver cancer is short, and it is difficult to detect early clinically. When the diagnosis is made, the disease is often in the middle or late stage, and the mortality rate is high.

At present, the treatment of liver cancer is mainly based on surgical resection, liver transplantation, local ablation, chemotherapeutic embolization and other local and regional treatments, molecular targeted therapy, etc., but the therapeutic effect of these methods is not ideal, because the natural immune system, specific Low immune function, low radical surgical resection rate, high recurrence rate after surgery, poor curative effect of radiation and chemotherapy, prone to intrahepatic dissemination and extrahepatic metastasis, so it is urgent to find new and effective methods to treat liver cancer

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