Compounds and their preparations that enhance the killing sensitivity of liver cancer cells to cik cells

Abstract

The invention discloses a compound for enhancing cytotoxic sensitivity of liver cancer cell against CIK cells, and a preparation thereof, and particularly provides applications of a pyridylbenzimidazole compound in preparing a drug for enhancing the cytotoxic sensitivity of liver cancer cell against CIK cells, and the pyridylbenzimidazole compound can be prepared into a pharmaceutically acceptable preparation, so as to achieve a good immune therapy effect with fewer CIK cells.

Description

technical field [0001] The invention belongs to the field of immunotherapy and relates to CIK cells, in particular to a compound and a preparation thereof for enhancing the killing sensitivity of liver cancer cells to CIK cells. Background technique [0002] Primary liver cancer (hereinafter referred to as liver cancer) is one of the most common malignant tumors in the world, with about 630,000 new cases every year, and the incidence rate has been on the rise in recent years. The disease course of liver cancer patients is short, and it is difficult to detect early clinically. When diagnosed, the disease is often in the middle or late stage, and the fatality rate is high. At present, the treatment of liver cancer is mainly based on surgical resection, liver transplantation, local ablation, chemotherapeutic embolization and other local and regional treatments, molecular targeted therapy, etc., but the therapeutic effect of these methods is not ideal, because the natural immune...

AI Technical Summary

Problems solved by technology

The disease course of patients with liver cancer is short, and it is difficult to detect early clinically. When the diagnosis is made, the disease is often in the middle or late stage, and the mortality rate is high.

At present, the treatment of liver cancer is mainly based on surgical resection, liver transplantation, local ablation, chemotherapeutic embolization and other local and regional treatments, molecular targeted therapy, etc., but the therapeutic effect of these methods is not ideal, because the natural immune system, specific Low immune function, low radical surgical resection rate, high recurrence rate after surgery, poor curative effect of radiation and chemotherapy, prone to intrahepatic dissemination and extrahepatic metastasis, so it is urgent to find new and effective methods to treat liver cancer

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