High performance liquid chromatographic analysis method and application of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium

A technology of high performance liquid chromatography and sodium propane sulfonate, which is applied to the analysis of materials, material separation, instruments, etc., can solve the problems of poor detection accuracy, large errors, and poor selectivity, and achieve high accuracy, small precision, The effect of method science

Active Publication Date: 2019-08-16
湖北吉和昌化工科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Iodometric method is a method that can detect sulfhydryl groups at present, but its selectivity is poor, the error is large, and the detection accuracy is poor

Method used

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  • High performance liquid chromatographic analysis method and application of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium
  • High performance liquid chromatographic analysis method and application of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium
  • High performance liquid chromatographic analysis method and application of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium

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Embodiment 1

[0109] 1, Determination of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium

[0110] 1.1 Chromatographic conditions of high performance liquid chromatography:

[0111] Chromatographic column: Hypersil ODS2, 5μ, 250mm×4.6mm (with Hypersil guard column);

[0112] Mobile phase composition volume ratio: acetonitrile: phosphate buffer = 10: 90; phosphate buffer is prepared by mixing 0.19mol / L phosphoric acid solution, 0.142mol / L triethylamine and 0.005mol / L dipotassium hydrogen phosphate solution made;

[0113] Flow rate: 1mL / min;

[0114] Column temperature: 25°C;

[0115] Detector: UV detector; detection wavelength: 230nm;

[0116] The injection volume is 20 μL.

[0117] 1.2 The method for the determination of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium by high performance liquid chromatography comprises the following steps:

[0118] Preparation of buffer and mobile phase: Accurately pipette 5mL of phosphoric acid and 10mL of triethylamine, accurately weigh 1.1...

Embodiment 2

[0158] 1, Determination of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium

[0159] 1.1 Chromatographic conditions of high performance liquid chromatography:

[0160] Chromatographic column: Hypersil ODS2, 5μ, 250mm×4.6mm (with Hypersil guard column);

[0161] Mobile phase composition volume ratio: methanol: phosphate buffer = 20: 80; phosphate buffer is prepared by mixing 0.19mol / L phosphoric acid solution, 0.142mol / L triethylamine and 0.005mol / L dipotassium hydrogen phosphate solution made;

[0162] Flow rate: 1.1mL / min;

[0163] Column temperature: 40°C;

[0164] Detector: UV detector; detection wavelength: 260nm;

[0165] The injection volume is 20 μL.

[0166] 1.2 The method for the determination of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium by high performance liquid chromatography comprises the following steps:

[0167]Preparation of buffer and mobile phase: Accurately pipette 5mL of phosphoric acid and 10mL of triethylamine, accurately weigh 1.14g ...

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Abstract

The invention discloses a high performance liquid chromatography method and application of sodium 3-(benzothiazol-2-ylthio)-propanesulfonate. The method comprises the following steps: (a) providing a 3-(benzothiazol-2-ylthio)-propanesulfonate (ZPS) reference substance solution and a test sample solution; (b) analyzing the ZPS content of the test sample solution in step (a) with HPLC-UV according to an external standard method. Detection conditions are as follows: a chromatographic column uses octadecyl silane bonded silica gel as a filler; a mobile phase is formed by an organic phase and a phosphate buffer, the pH of a phosphate buffer is equal to 5.5 plus / minus 0.1, and the volume ratio of the organic phase to the phosphate buffer is (10 to 90) to (80 to 20); the detection wavelength is between 190nm and 330nm. The technical problems of imperfect measurement method of ZPS content, poor selectivity of iodometric method and poor accuracy are alleviated. The method can accurately detect the ZPS content, so that the precision is good, and the accuracy is high.

Description

technical field [0001] The present invention relates to the analytical method technical field of 3-(benzothiazole-2-mercapto)-propanesulfonate sodium, specifically, relate to a kind of efficient Liquid chromatography analysis methods and applications. Background technique [0002] 3-(benzothiazol-2-mercapto)-sodium propanesulfonate (ZPS), English name: Sodium 3-(ben-zothiazol-2-ylthio)-1-propanesulfonate, mainly used in electroplating acid copper plating, as The brightener in acidic copper plating is the main additive in copper plating additives. It can be used in conjunction with polyether and wetting agent to obtain a bright, ductile and good coating. It can also be used in conjunction with other sulfur-containing brighteners. It can also be used in electroless plating of precious metals to prevent irregular deposition. [0003] In the entire acid copper brightener market, this product is in great demand and has excellent application effects. In the copper plating additi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 付启龙周世骏杨威黄开伟宋文华
Owner 湖北吉和昌化工科技有限公司
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