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Application of miRNA marker in preparation of cervical intraepithelial neoplasia agent for screening folic acid deficiency populations

A technology for screening folic acid and folic acid deficiency, which is applied in the fields of genetic engineering and clinical medicine, and can solve problems such as folic acid deficiency

Inactive Publication Date: 2017-07-11
THE SECOND HOSPITAL OF SHANXI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] However, does folate deficiency participate in the progression of CIN to cervical cancer by regulating the abnormal expression of miRNA? At present, there is no literature report at home and abroad

Method used

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  • Application of miRNA marker in preparation of cervical intraepithelial neoplasia agent for screening folic acid deficiency populations
  • Application of miRNA marker in preparation of cervical intraepithelial neoplasia agent for screening folic acid deficiency populations
  • Application of miRNA marker in preparation of cervical intraepithelial neoplasia agent for screening folic acid deficiency populations

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Embodiment Construction

[0037] Application of a miRNA marker in preparation of cervical intraepithelial neoplasia reagents for screening folic acid deficiency groups, the folic acid deficiency standard is that serum folic acid is not greater than 10nmol / L, and the miRNA markers include: miRNA is 14 ; miR-10a, miR-375, miR-23a, miR-18a, miR-6774, miR-21, miR-3613, miR-4730, miR-1247, miR-3607, miR-224, miR-30a, miR -30c, miR-196b.

[0038] 1 Objects and methods

[0039] 1.1 Research object

[0040] 1.1.1 Inclusion criteria of research objects

[0041] Patients with gynecological diseases who were treated in our hospital from January to December 2013 were selected, and TCT was used to detect cervical exfoliated cells to exclude those with abnormal cervical gland cells. For those with TCT results of ASCUS and above, further colposcopy biopsy and histopathological examination were performed. . At the same time, the flow-through hybridization chip technology (HybriMax) was used for HPV type detection....

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Abstract

The invention relates to the fields of genetic engineering and clinical medicine science, and concretely relates to an application of an miRNA marker in the preparation of a cervical intraepithelial neoplasia agent for screening folic acid deficiency populations. The folic acid concentration which is not more than 10 nmol / L is judged as folic acid deficiency, and the miRNA marker comprises the following fourteen miRNAs: miR-10a, miR-375, miR-23a, miR-18a, miR-6774, miR-21, miR-3613, miR-4730, miR-1247, miR-3607, miR-224, miR-30a, miR-30c and miR-196b. A reagent or a kit can be used for inspecting the expression condition of the 14 miRNAs in cervical tissues of folic acid deficiency patients in order to analyze the CIN and cervical cancer suffering risk of like populations.

Description

technical field [0001] The invention relates to the fields of genetic engineering and clinical medicine, in particular to the application of a miRNA marker in the preparation of cervical intraepithelial neoplasia reagents for screening folic acid deficiency populations. Background technique [0002] The incidence of cervical cancer (CC) ranks second among female malignant tumors in developing countries. According to statistics, there are 500,000 new cases in the world every year, and my country accounts for 25%. The fatality rate is 11.30%, which is much higher than that in developed countries. Shanxi Province is a high-incidence area of ​​cervical cancer, among which Yangcheng County in our province is still the area with the highest incidence rate (78.23 / 100,000) and mortality rate (25.07 / 100,000) of cervical cancer in China, which is much higher than the average rate of cervical cancer in my country during the same period. Morbidity (9.62 / 100,000) and mortality (2.54 / 100,0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/178
Inventor 郝敏赵卫红王志莲杨欣王伟
Owner THE SECOND HOSPITAL OF SHANXI MEDICAL UNIV
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