Specific yolk liquid antibody preparation using corn cob as carrier and preparation method of specific yolk liquid antibody preparation

A corn cob, specific technology, applied in the direction of antibodies, chemical instruments and methods, carrier binding/immobilization of peptides, etc., can solve the problems of loss of active ingredients, large energy, consumption, etc., to achieve changes in microscopic properties, increase specific surface area, cost reduction effect

Inactive Publication Date: 2017-07-14
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to directly mix the specific egg yolk liquid with the corn cob carrier that has been treated by micro-cutting and assisting interaction to solve the problems of loss of active ingredients and large energy consumption, reduce production costs, and simplify the preparation process from the perspective of cost saving

Method used

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  • Specific yolk liquid antibody preparation using corn cob as carrier and preparation method of specific yolk liquid antibody preparation
  • Specific yolk liquid antibody preparation using corn cob as carrier and preparation method of specific yolk liquid antibody preparation
  • Specific yolk liquid antibody preparation using corn cob as carrier and preparation method of specific yolk liquid antibody preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0028] The corncob coarse powder is ultrafinely pulverized, and an auxiliary agent is added during the ultrafine pulverization, the auxiliary agent used is calcium carbonate, the auxiliary agent dosage is 5% (w / w), and the pulverization time is 10 minutes.

[0029] By comparing the scanning electron microscope photos, it can be found that the surface of the corncob carrier treated by the micro-cutting-assisted interaction technology is rougher, the surface area becomes larger, and the binding and adsorption capacity is correspondingly stronger. Experiments have shown that compared to common corncob carriers (see figure 1 ), the corncob carrier processed by the micro-cutting aided interaction technology (see figure 2 ) The adsorption capacity can be increased by 30% to 100%.

[0030] After the corn cob powder is treated with the micro-cutting aid interaction technology, it is passed through a 100-mesh sieve, and 300g is weighed for later use; the high-immune eggs immunized wi...

Embodiment 2

[0032] The preparation method of the micro-cut corncob carrier is the same as in Example 1.

[0033] After the corncob powder is treated with the micro-cutting aid interaction technology, pass through a 60-mesh sieve, and weigh 500g for later use; use the egg yolk separator to take 900g of the egg yolk into the container after being immunized with inactivated Vibrio splendidus , stir; stir the egg yolk until the volume expands, the color becomes lighter, and becomes thick; add 1.5g potassium sorbate, 4.5g calcium propionate, 0.38g ethoxyquinoline, and stir well; put the spare 500g corncob Add the powder into the egg yolk liquid, stir until uniform, and form a lumpy solid with moderate hardness; then use a granulator to make soft particles with a diameter of 3mm; dry at room temperature; crush with a pulverizer, pass through a 100-mesh sieve, and pack; Made into feed additives.

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Abstract

The invention discloses a specific yolk liquid antibody preparation using a corn cob as a carrier. The specific yolk liquid antibody preparation comprises specific yolk liquid, a mirco-cut corn cob carrier, potassium sorbate, ethoxyquin and calcium propionate. The invention further provides a preparation method of the specific yolk liquid antibody preparation using a corn cob as a carrier. The preparation method comprises the following steps of taking the specific yolk liquid, adding the potassium sorbate, the calcium propionate and the ethoxyquin, performing micro cutting on the corn cob carrier, and performing stirring to make soft granules; and performing drying, performing crushing, and performing screening, so as to make a yolk antibody preparation. The specific yolk liquid and the corn cob meal are subjected to mixed processing, so that the loss of the yolk antibody is reduced, the difficult problem of energy consumption is solved, the cost is reduced, the production technology is simplified, and the specific yolk liquid antibody preparation is suitable for mass production. According to the specific yolk liquid antibody preparation disclosed by the invention, a micro-cut interaction support technique is combined, so that the biological availability of effective components is improved. The specific yolk liquid antibody preparation is suitable for stichopus japonicus, turbot, cows, piggies and the like, and can prevent and treat bacterial infection or other immunological diseases, and increase the survival rate of animals and enhance the immunity of the animals.

Description

technical field [0001] The invention relates to the technical field of biological feed, and more specifically relates to a specific yolk liquid yolk antibody preparation and a preparation method thereof, which use corn cobs treated with microcutting assistance and interaction as a carrier. Background technique [0002] Drug residues caused by the use of antibiotics have become a major problem restricting the competitiveness of my country's aquatic products in the international market. Yolk antibody (IgY) has the advantages of non-toxicity, no residue, and no drug resistance, and its development prospects have attracted much attention. In addition, IgY has the advantages of low preparation cost, high output rate, simple and quick purification, heat resistance and good stability, and has been widely made into products for the prevention and treatment of animal diseases. For example, the prepared IgY preparation is used to feed sea cucumbers to prevent and treat sea cucumber r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K10/37A23K10/20C07K17/02C07K16/02C07K16/12A61K39/395A61P31/04A61P37/04
CPCA61K2039/505C07K16/02C07K16/1239C07K17/02Y02P60/87
Inventor 李晓宇杜正江徐永平徐乐王丽丽
Owner DALIAN UNIV OF TECH
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