Hydrogel with multiple response function and preparation method and application thereof

A multi-response, hydrogel technology, applied in the field of biomedical materials, to achieve excellent mechanical properties, biocompatibility, and easy molding

Active Publication Date: 2017-08-11
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the defect that the existing hydrogel can only respond to a single external stimulus, the primary purpose of the present invention is to provide a method for preparing a hydrogel with multiple response functions

Method used

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  • Hydrogel with multiple response function and preparation method and application thereof
  • Hydrogel with multiple response function and preparation method and application thereof
  • Hydrogel with multiple response function and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of hydrogel material comprises the following steps:

[0048] (1) Preparation of modified hydrogel material: 12.6g of Pluronic F-127 was dissolved in 100mL of a mixed solution with a volume ratio of dichloromethane: acetone = 1:1, and 3mL of acryloyl chloride and 3mL of Tris were added dropwise in an ice bath. Ethylamine, react in ice bath for 12h, and react at room temperature for 12h. After the reaction, washed with saturated sodium bicarbonate solution, rotary evaporated and vacuum dried at 40° C. for 24 hours to obtain modified F-127 (12 g).

[0049] (2) Preparation of modified double selenium: After synthesizing the double selenide product according to the literature, get 1g of double selenide and dissolve it in 50mL dichloromethane solution, feed nitrogen gas into the reaction system for half an hour, then ice bath 6 mL of acryloyl chloride and 7 mL of triethylamine were added dropwise, reacted in ice bath for 3 h, and reacted at room temperature f...

Embodiment 2

[0052] Preparation of hydrogel materials

[0053] In the step (3) of Example 1, "the modified di-selenide material of 10g and the photopolymerization initiator of 10g are dissolved in the vinylpyrrolidone solution of 100mL" to be changed into "the modified di-selenide material of 20g and the photopolymerization initiator of 10g Photopolymerization initiator is dissolved in the vinylpyrrolidone solution of 100mL", all the other are identical with embodiment 1. At this point in the final mixed solution, the mass ratio of the modified di-selenium material to the modified F-127 is 1:10.

Embodiment 3

[0055] Preparation of hydrogel materials

[0056] In the step (3) of Example 1, "the modified di-selenide material of 10g and the photopolymerization initiator of 10g are dissolved in the vinylpyrrolidone solution of 100mL" to be changed into "the modified di-selenium material of 30g and the photopolymerization initiator of 10g Photopolymerization initiator is dissolved in the vinylpyrrolidone solution of 100mL", all the other are identical with embodiment 1. At this point in the final mixed solution, the mass ratio of the modified di-selenium material to the modified F-127 is 3:20.

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Abstract

The invention discloses hydrogel with multiple response function and a preparation method and application thereof; the preparation method of the hydrogel comprises the steps of adding hydrogel material, acryloyl chloride and triethylamine into a solvent, and reacting under ice bath to obtain modified hydrogel material; adding diselenide-diol, acryloyl chloride and triethylamine into a solvent, reacting under ice bath to obtain modified diselenide with C-C double bond; mixing the modified hydrogel material solution with the modified diselenide solution, adding a photo-polymerization initiator, and irradiating in ultraviolet at 20-40 DEG C to generate hydrogel having multiple response function. The hydrogel material is responsive to temperature, light and redox, quick gelling can be achieved by adjusting temperature, bulk concentration, photo-polymerization initiator concentration and a light source, the hydrogel is easy to form and has excellent mechanical properties and biocompatibility, and redox responsiveness of the hydrogel helps load different drug molecules and release them effectively.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a hydrogel with multiple response functions, a preparation method and application thereof. Background technique [0002] Hydrogel is a kind of hydrophilic polymer composed of polymer chain segments and having a three-dimensional cross-linked network structure. Hydrogels can absorb and retain large amounts of water but are insoluble in water and maintain structural integrity in solution and in living organisms. Because hydrogel has high water permeability and good biocompatibility, and has a certain strength, and the surface structure is similar to biological tissue, it has received more and more attention and applications in the field of biomaterials, such as contact lenses , sustained and controlled release of drugs, construction of tissue scaffolds, medical dressings, etc. [0003] According to the response of hydrogels to external stimuli, they are generally divided into ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F290/06C08F230/00C08F2/48B33Y70/00A61K47/32A61K47/10C08L51/08
CPCA61K47/10A61K47/32B33Y70/00C08F2/48C08F290/06C08J3/075C08J2351/08C08F230/00
Inventor 薛巍张洁玲马栋王永周
Owner JINAN UNIVERSITY
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