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Methods of treating cancer using tigit inhibitors and anti-cancer agents

A technology of anticancer agent and therapy, applied in the field of using TIGIT inhibitor and anticancer agent to treat cancer

Inactive Publication Date: 2017-08-18
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, many cancers are also interconnected with the immune system, as various immune cells are able to mount responses against cancer cells, but cancer cells also possess mechanisms to suppress or evade these responses

Method used

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  • Methods of treating cancer using tigit inhibitors and anti-cancer agents

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Embodiment Construction

[0028] I. General Technology

[0029] The techniques and procedures described or referred to herein are generally well understood and commonly employed by those skilled in the art, using conventional methods such as, for example, the widely utilized method described in Sambrook et al., Molecular Cloning: A Laboratory Manual 3d edition ( 2001) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.; Current Protocols in Molecular Biology (F.M.Ausubel et al., (2003)); Series Methods in Enzymology (Academic Press, Inc.): PCR2: A Practical Approach (M.J.MacPherson, B.D.Hames and G.R.Taylor, (1995)), Harlow and Lane (1988) Antibodies, A Laboratory Manual, and Animal Cell Culture (R.I. Freshney, (1987)); Oligonucleotide Synthesis (M.J. Gait, 1984); Methods in Molecular Biology, Humana Press; Cell Biology: A Laboratory Notebook (ed. J.E. Cellis, 1998) Academic Press; Animal Cell Culture (ed. R.I. Freshney), 1987); Introduction to Cell and Tissue Culture (J.P. Mather and P.E.Rob...

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Abstract

The present disclosure provides methods comprising administering to the individual an effective amount of an agent that decreases or inhibits TIGIT expression and / or activity and an anti-cancer agent and / or an anti-cancer therapy. Further provided are kits comprising an anti-cancer agent, an agent that decreases or inhibits TIGIT expression and / or activity, or both, as well as instructions for use thereof.

Description

[0001] Cross references to related applications [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 025,394, filed July 16, 2014, the contents of which are hereby incorporated by reference in their entirety. [0003] Submission of a sequence listing as an ASCII text file [0004] The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: Sequence Listing in Computer Readable Format (CRF) (File Name: 146392027240SEQLISTING.TXT, Date of Record: 9 Jul 2015, Size: 11 KB). [0005] field of invention [0006] The present disclosure relates to methods of treating cancer and / or tumor immunity by administering agents that reduce or inhibit TIGIT expression and / or activity and anticancer agents and / or anticancer therapies. [0007] Background of the invention [0008] Many immune-related diseases are known and have been extensively studied. Such diseases include immune-mediated inflammatory disea...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K31/7088A61P35/00
CPCA61K31/7088A61K45/06C07K16/2803A61K38/193A61K38/20A61K38/217A61K47/6851A61P35/00A61K38/00A61K39/39558Y02A50/30A61K39/001104A61K39/001129A61K39/001113A61K39/001128A61K39/00117A61K39/001119A61K39/001106A61K39/001109A61K39/001124A61K39/001166A61K39/00114A61K39/0011A61K39/001138A61K39/001141A61K2039/5158A61K2300/00A61K47/6803A61K2039/505A61K2039/545C07K16/30C07K2317/51C07K2317/515C07K2317/56C07K2317/76C12N15/1138C12N15/115C12N2310/11C12N2310/12C12N2310/14
Inventor J·L·格罗甘
Owner F HOFFMANN LA ROCHE & CO AG
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