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Multifunctional heating and pressure extraction-trapping-chromatographic separation online combined equipment

A technology of heating and pressurizing and chromatographic separation, which is applied in the direction of material separation, analysis materials, instruments, etc., can solve the problems of unachievable and unrealizable method conversion, and achieve the effect of increasing diversification, improving sensitivity and reproducibility

Active Publication Date: 2019-08-20
SHIMADZU (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, various pretreatment methods and separation methods are mostly used independently or offline, and the combination of online pretreatment and separation cannot be realized, let alone the conversion between methods

Method used

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  • Multifunctional heating and pressure extraction-trapping-chromatographic separation online combined equipment
  • Multifunctional heating and pressure extraction-trapping-chromatographic separation online combined equipment
  • Multifunctional heating and pressure extraction-trapping-chromatographic separation online combined equipment

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Embodiment 1

[0049] Supercritical Fluid Extraction-Reverse Phase Extraction Column Trap-Supercritical Fluid Chromatography Online Combined Analysis Mode

[0050] This embodiment provides the supercritical fluid extraction-reverse phase extraction column trapping-supercritical fluid chromatography on-line combined analysis mode of the multifunctional heating and pressure extraction-trapping-chromatographic separation online combined equipment, which is suitable for It is suitable for the extraction, enrichment and separation of low and medium polar compounds. In this implementation, the trapping column is a reversed-phase extraction column, the chromatographic column 32 is a reversed-phase chromatographic column dedicated to supercritical fluid, and the heating and pressurizing extraction unit 24 is heated and pressurized by introducing liquid carbon dioxide. That is to realize carbon dioxide supercritical fluid extraction, and the specific analysis steps of the analysis mode are as follows...

Embodiment 2

[0058] Accelerated solvent extraction-hydrophilic interaction extraction column trapping-hydrophilic interaction chromatography separation online combined analysis mode

[0059] This embodiment provides an accelerated solvent extraction-hydrophilic interaction extraction column trapping-hydrophilic interaction chromatography online combined analysis mode of the multifunctional heating and pressure extraction-trapping-chromatographic separation online combined device, This mode is suitable for extraction, enrichment and separation of medium and high polar compounds. In this embodiment, the trapping column 15 is a short chromatographic column for hydrophilic interaction, the chromatographic column 32 is a chromatographic column for hydrophilic interaction, and the heating and pressure extraction unit 24 only introduces acetonitrile, and the heating and After pressing, accelerated solvent extraction is realized, and the specific analysis steps of the analysis mode are as follows:...

Embodiment 3

[0067] Supercritical fluid extraction-supercritical fluid chromatography separation analysis mode

[0068] This embodiment provides the supercritical fluid extraction-supercritical fluid chromatography separation analysis mode of the multifunctional heating and pressure extraction-capture-chromatographic separation online combined device. The carbon dioxide is heated and pressurized to realize the carbon dioxide supercritical fluid extraction function. see Figure 12, which is a schematic diagram of flow communication in this embodiment. The specific analysis steps of the analysis mode are: the first high-pressure six-way switching valve 11 is in the "1" position, and the pressure of the first back pressure regulator 26 is Set to 10MPa, the pressure of the second back pressure regulator 27 is set to 40MPa; at this time, the second chromatographic pump 21 pushes liquid carbon dioxide, and the third chromatographic pump 22 pushes modifier, and the liquid carbon dioxide and modi...

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Abstract

A multifunctional on-line combination device for temperature and pressure increase-assisted extraction, trapping, and chromatographic separation, comprising four chromatographic pumps (16, 21, 22, 23), three three-way mixers (13, 14, 28), two six-way switching valves (11, 12), a temperature and pressure increase-assisted extracting unit (24), a trapping column (15), a chromatographic column (32), detectors (33, 34), etc. By on-line combining a trapping-desorption-switching device and an extraction-chromatographic separation device to control the switching of the two high pressure six-way switching valves (11, 12) and the pressure adjustment of back pressure regulators (26, 27), it is possible to automatically realize free combinations of two extraction forms, i.e. supercritical fluid extraction and accelerated solvent extraction, and two chromatography technologies, i.e. supercritical fluid chromatography and high-performance liquid chromatography, increasing the functional diversification of the device, being able to be effectively used in on-line extraction, trapping, desorption, separation and detection of trace targets in complex solid or semi-solid samples in the fields of environment, food, medicine, biology, etc.

Description

technical field [0001] The invention belongs to the field of analytical chemical sample pretreatment, in particular to the design, analysis and application of a multifunctional heating and pressure extraction-capture-chromatographic separation on-line combined equipment, which is suitable for solid or Online extraction, capture, desorption, separation and detection of trace organics in semi-solid samples. Background technique [0002] Heating and pressurizing during the extraction process can greatly improve the extraction speed and recovery rate. Among them, supercritical fluid extraction (SFE) and accelerated solvent extraction (ASE) are two common pretreatment extraction technologies. . Specifically, SFE usually uses carbon dioxide as a fluid, and can be converted into a supercritical fluid by heating and pressurizing to supercritical conditions, which has the advantages of green, safe, and high extraction efficiency; ASE can be quickly extracted with organic solvents by...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/72
Inventor 钟启升刘佳琪申玲玲姚劲挺黄涛宏
Owner SHIMADZU (CHINA) CO LTD
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