The invention discloses a four-degree of freedom parallel-series hybrid oscillating screen, which comprises a base, a crank block mechanism, a support, an intermediate platform, a Y left branch chain, a Y right branch chain, an X front branch chain, an X rear branch chain and a screen box, wherein the crank block mechanism is arranged above the base; the bottom part of the support is arranged on the crank block mechanism; the upper end of the support is fixedly connected with the intermediate platform; the screen box is arranged above the intermediate platform; the Y right branch chain, the Xfront branch chain, the Y left branch chain and the X rear branch chain are connected between the screen box and the intermediate platform; and the screen box, the intermediate platform and the four branch chains which are connected with the screen box and the intermediate platform form a parallel mechanism with a 4-spherical pair-prismatic pair-revolute pair (4SPR) structure. The oscillating mechanism disclosed by the invention is a parallel-series hybrid mechanism 4-spherical pair-prismatic pair-revolute pair-parallel (4SPR-P), which is capable of realizing two-shift and two-rotation oscillation of four degrees of freedom on the screen box; the oscillating amplitude, the frequency, the dip angle and the oscillating degree of freedom can be regulated. The four-degree of freedom parallel-series hybrid oscillating screen has strong adaptability on different screened materials and can be used for material grading in industry of energy, metallurgy, building material, chemical engineering, agriculture and grain processing.