The preparation method of the total saponins of Chonglou self-microemulsification granule

Abstract

The invention discloses a preparation method of total saponins self-microemulsifying granules of Pachyphylla saponins, which comprises the following steps: weighing 7.0 g of propylene glycol monocaprylate, 1.5 g of Tween-80 and 1.5 g of propylene glycol and mixing them evenly with magnetic force, then slowly adding 0.1g total saponins of Chonglou, and magnetically stirred to dissolve the medicine completely, so as to obtain the self-microemulsification drug release system of total saponins of Chonglou; take 50.0g microcrystalline cellulose and place it in a mortar, and slowly add dropwise 10.0g of the obtained The solution of the total saponins of Chonglou self-microemulsification drug delivery system is added while stirring evenly, and then 10.0% of PVP K30 solution is added to make a soft material. When the soft material reaches the state of being held in a ball and lightly pressed to disperse, stop adding liquid; The obtained soft material is granulated through a sieve, dried, and granulated to obtain the final product. The invention prepares the total saponins of papaya papaya into self-microemulsifying granules, which can significantly improve the in vitro dissolution rate of medicines, and the preparation process is simple and feasible.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical preparation, and more particularly to a method of preparing a heavy-housing total saponin from the microemulsion particulate agent. Background technique [0002] The Paris Polyphylla is a lily (Jiliaceae), also known, in recent years, pharmacological research has shown that the total saponins of heavy buildings have inhibiting tumor effects. [1] However, the anti-tumor activity of heavy buildings in heavy buildings in heavy buildings is the strongest. At present, the clinical application of heavy buildings, a mixture, lotion, aerosol, paste and other dosage forms, but mostly for medicinal powder or extract, after the dosage form, the effective ingredient in the formulation is low, bio-utilization Degree. Since the total saponin of the heavy building is a lipid-soluble component, its conventional solution preparation has a disadvantage of absorption, and the low biological utilization degree is low...

AI Technical Summary

Problems solved by technology

At present, Chonglou preparations in clinical application have various dosage forms such as powders, formulations, lotions, aerosols, ointments, etc., but most of them are medicinal powders or extracts directly used in medicine, the dosage forms are backward, and the content of active ingredients in the preparations is low. Bioavailability degree difference

Because the total saponins of Parisia saponins are fat-soluble components, their common solution preparations have disadvantages such as poor absorption and low bioavailability, which seriously affect the clinical efficacy of the drug

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