Human tumor-related methylation site as well as screening method and use thereof

Abstract

The invention provides a human tumor-related methylation site as well as a screening method and use thereof. The human tumor-related methylation site is selected from at least one methylation site on a human 18th chromosome, a human third chromosome and a human second chromosome; the change of methylation site, caused by BMI, on chromosomes is related to a human endometrial cancer; prognosis on a human tumor can be performed by detecting the methylation site changes on the chromosomes; the human tumor-related methylation site can be used as a potential prognosis marker of the tumor, and especially can be used as a prognosis marker of the human endometrial cancer.

Description

technical field

[0001] The invention belongs to the technical field of diagnosis and detection of endometrial cancer, and in particular relates to a human tumor-related methylation site and its screening method and application. Background technique

[0002] Endometrial cancer is a group of epithelial malignant tumors that occur in the endometrium, and it is more common in perimenopausal and postmenopausal women. Endometrial cancer is one of the most common female reproductive system tumors, with nearly 200,000 new cases each year, and is the third most common gynecological malignancy leading to death. Due to the complex pathogenic factors and unknown pathogenesis, early diagnosis and detection of endometrial cancer are very difficult, and endometrial cancer is often found to be in the middle and advanced stages, causing patients to miss the best opportunity for endometrial cancer treatment.

[0003] In recent years, studies have shown that DNA methylation can be used as a b...

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