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Preservation method of terminal olefin type rare ginsenosides

A technology of ginsenosides and terminal olefins, which is applied in the chemical field, can solve the problems of increasing the difficulty of long-term storage of terminal olefins rare ginsenosides, achieve storage cost acceptance, improve stability, and avoid conversion effects

Active Publication Date: 2017-11-10
上海中盈经济发展(集团)股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This phenomenon increases the difficulty of long-term storage of terminal ethylenic rare ginsenosides

Method used

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  • Preservation method of terminal olefin type rare ginsenosides
  • Preservation method of terminal olefin type rare ginsenosides
  • Preservation method of terminal olefin type rare ginsenosides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The storage of embodiment 1Rk2

[0023] Rk2 is self-made with a purity greater than 95%. Take 60mg Rk2 and divide into six 1.5mL EP tubes, each EP tube contains about 10mg Rk2, and they are labeled 1-6 respectively.

[0024] Store the samples numbered 1-3 in a refrigerator at 4°C; put the samples numbered 4-6 in an ultraviolet light box, adjust the ultraviolet wavelength in the light box to 360nm, and place them at room temperature.

[0025] After storage for 6 months, the contents of Rk2 and (E)-Rh3 in samples numbered 1-6 were measured respectively.

[0026] As a result, the average Rk2 content in samples 1-3 was 81.5%, and the average (E)-Rh3 content was 17.6%; the average Rk2 content in samples 4-6 was 96.2%, and the average (E)-Rh3 content was 3.1%.

Embodiment 2

[0027] The storage of embodiment 2Rk3

[0028] Rk3 is self-made with a purity greater than 95%. Take 60mg of Rk3 and divide into six 1.5mL EP tubes, each EP tube contains about 10mg of Rk3, and they are respectively labeled 1-6.

[0029] Store the samples numbered 1-3 in a refrigerator at 4°C; put the samples numbered 4-6 in an ultraviolet light box, adjust the ultraviolet wavelength in the light box to 360nm, and place them at room temperature.

[0030] After storage for 6 months, the contents of Rk3 and (E)-Rh4 in samples numbered 1-6 were measured respectively.

[0031] As a result, the average Rk3 content in samples 1-3 was 79.5%, and the average (E)-Rh4 content was 19.6%; the average Rk3 content in samples 4-6 was 96.8%, and the average (E)-Rh4 content was 2.5%.

Embodiment 3

[0032] The storage of embodiment 3Rg6

[0033] Rg6 is self-made with a purity greater than 95%. Take 60mg of Rg6 and divide into six 1.5mL EP tubes, each EP tube contains about 10mg of Rg6, and they are respectively labeled 1-6.

[0034] Store the samples numbered 1-3 in a refrigerator at 4°C; put the samples numbered 4-6 in an ultraviolet light box, adjust the ultraviolet wavelength in the light box to 360nm, and place them at room temperature.

[0035] After storage for 6 months, the contents of Rg6 and (E)-F4 in samples numbered 1-6 were determined respectively.

[0036] As a result, the average Rg6 content in samples 1-3 was 76.4%, and the average (E)-F4 content was 22.8%; the average Rg6 content in samples 4-6 was 97.6%, and the average (E)-F4 content was 2.0%.

[0037] To sum up, the storage method provided by the present invention can significantly improve the stability of terminal alkene-type rare ginsenosides, and avoid its transformation into E-type rare ginsenosid...

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Abstract

The invention discloses a preservation method of terminal olefin type rare ginsenosides. To be specific, the terminal olefin type rare ginsenosides are preserved under 360 + / - 2 nm ultraviolet light. The terminal olefin type rare ginsenosides comprise ginsenoside Rk2, ginsenoside Rk3 and ginsenoside Rk6. The rare ginsenosides have different stability due to tiny difference between chemical structures of olefin type, Z type and E type rare ginsenosides, wherein the E type rare ginsenoside is the most stable. The olefin type rare ginsenosides are found to be gradually converted into the E type rare ginsenoside during preservation. With the adoption of the preservation method, the stability of olefin type rare ginsenosides can be significantly improved, and the olefin type rare ginsenosides can be prevented from being converted into the E type rare ginsenosides. The method is easy to implement and the preservation cost is also acceptable.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to a method for preserving rare ginsenosides of terminal alkenes. Background technique [0002] The C20 position of dammarane-type ginsenosides mostly has a hydroxyl group, which is widely found in plants of the genus Panax genus, and its content is relatively high. After heat treatment, the C20 hydroxyl group of dammarane type saponins and their aglycones is prone to dehydration reaction, forming double bonds, and generating a series of C20 dehydroxylated dammarane type rare ginsenosides and their aglycones. [0003] When the C20 hydroxyl group undergoes a dehydration reaction, isomers 1-3 (belonging to rare saponins) will be generated, and the double bond of isomer 1 is formed between C20 and C21 (terminal type), isomerism The double bond of isomers 2 and 3 is formed between C20 and C22, but one of isomers 2 and 3 is E-type and the other is Z-type, as shown in the following f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J17/00C07J9/00
Inventor 陈云张思静王斌
Owner 上海中盈经济发展(集团)股份有限公司
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