Preparation method of artemisinin slow-release system

Abstract

The invention relates to a preparation method of an artemisinin slow-release system. The preparation method is characterized by comprising steps as follows: 1) artemisinin is dissolved with ethylis oleas, a cosolvent and an emulsifier are added, and the emulsified artemisinin is added to a sodium alginate solution; 2) the solution is dropwise added to a glacial acetic acid solution containing chitosan and calcium chloride, and microspheres are formed; 3) the microspheres are cooled to the room temperature and mixed with a crosslinking agent, the stirring speed is controlled to be 500 r / min-1,000 r / min, the crosslinking agent is glutaraldehyde or glyceraldehyde, and consumption of the crosslinking agent accounts for 1%-4% of the mass of the reaction system; 4) suction filtration is performed, and the mixture is washed 5-8 times with petroleum ether and distilled water; 5) the artemisinin slow-release system is obtained after drying is performed for 36-72 h. The inhibition time of artemisinin for blue-green algae in water can be prolonged effectively, the cost is reduced, and artemisinin can be used for ponds, reservoirs, lakes and other natural water to inhibit outbreak of algae.

Description

technical field [0001] The invention relates to a preparation method of an artemisinin sustained-release body. Background technique [0002] Artemisinin is a colorless needle-like crystal extracted from the leaves of the compound inflorescence plant Artemisia annua, which is the traditional Chinese medicine Artemisia annua. Its stem does not contain the drug Artemisia annua. The most effective antimalarial drugs after that, especially for cerebral malaria and anti-chloroquine malaria, have the characteristics of quick action and low toxicity. Capsules containing artemisinin are needed to treat diseases, but the current application of artemisinin is for However, there is no relevant research on the algae inhibition of artemisinin. The more mature microcapsule technology is used to inhibit algae in real water, broaden its application field, and provide a new technical approach for algae inhibition in real water. Contents of the invention [0003] The object of the present i...

AI Technical Summary

Problems solved by technology

[0002] Artemisinin is a colorless needle-like crystal extracted from the leaves of the compound inflorescence plant Artemisia annua, which is the traditional Chinese medicine Artemisia annua. Its stem does not contain the drug Artemisia annua. The most effective antimalarial drugs after that, especially for cerebral malaria and anti-chloroquine malaria, have the characteristics of quick action and low toxicity. Capsules containing artemisinin are needed to treat diseases, but the current application of artemisinin is for However, there is no relevant research on the algae inhibition of artemisinin. Using relatively mature microcapsule technology, it is applied to inhibit algae in real water bodies, broaden its application fields, and provide a new technical approach for algae inhibition in real water bodies.