β-amyloid fibrinolytic agent, therapeutic/preventive drug for diseases caused by β-amyloid fibrosis

Abstract

The present invention is to provide a β-amyloid fibrinolytic agent containing a natural product as an active ingredient, and a therapeutic drug or preventive drug for diseases caused by β-amyloid fibrosis. It is a β-amyloid fibrinolytic agent, a therapeutic drug or a preventive drug for a disease caused by β-amyloid fibrosis, containing a dry powder, ground material and / or extract of earthworms as an active ingredient. The disease caused by fibrosis of beta amyloid is preferably Alzheimer's disease.

Description

technical field [0001] The present invention relates to a beta-amyloid fibrinolytic agent and a therapeutic / preventive drug for a disease caused by beta-amyloid fibrosis. Background technique [0002] Amyloid beta (also called amyloid beta protein or amyloid beta peptide) is known to be a protein comprising amino acids of about 40 residues, and in the brains of Alzheimer's patients, amyloid beta aggregates and Accumulation of fibrotic beta amyloid fibrils. β-amyloid is a water-soluble protein released extracellularly, and itself does not show toxicity to nerve cells, but is toxic to nerve cells by forming β-amyloid fibers (for example, Patent Document 1). Therefore, it is considered that β-amyloid fibers The accumulation of is one of the causes of Alzheimer's disease. [0003] The major molecular species known as β-amyloid proteins are β-amyloid 40 with Val at the C-terminus of 40 residues and β-amyloid 42 with 42 residues and with Ala at the C-terminus. In the nerve cell...

AI Technical Summary

Problems solved by technology

[0006] However, there have been no reports of prevention / treatment of Alzheimer's disease using earthworms so far.

Images