Method for measuring content of free hemoglobin by double-optical-path multiposition modulating light source

A technology of hemoglobin and modulated light source, applied in color/spectral characteristic measurement, measurement device, material analysis by optical means, etc., to improve accuracy, eliminate the influence of light source changes and blood bags, and eliminate the influence of background noise. Effect

Inactive Publication Date: 2017-12-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The invention provides a method for measuring the content of free hemoglobin with dual optical paths and multi-position modulated light sources, which not only eliminates the effects of spectral background noise, light source changes, and blood bags, but also g...

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  • Method for measuring content of free hemoglobin by double-optical-path multiposition modulating light source
  • Method for measuring content of free hemoglobin by double-optical-path multiposition modulating light source
  • Method for measuring content of free hemoglobin by double-optical-path multiposition modulating light source

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Embodiment 1

[0076] The embodiment of the present invention provides a method for measuring free hemoglobin content with a dual optical path and a multi-position modulated light source. The devices used are such as image 3 As shown, it includes: a light source 3 , a blood bag 5 , a displacement platform 6 , a spectrum receiving device 7 and a modulation device 9 .

[0077] Ensure that the light output port of the light source 3 and the incident slit of the spectrum receiving device 7 are close to the blood bag 5, and the modulation device 9 modulates the light source 3 so that it sends out a square wave light signal. The light source 3 is under the two optical paths at position a, namely: a (corresponding to the first optical path 1) and position a' (corresponding to the second optical path 2) transmit the blood sample in the blood bag 5, and the transmission spectrum is collected by the spectrum receiving device 7; then the light source 3 is controlled to move by the displacement platform...

Embodiment 2

[0086] The difference between the embodiment of the present invention and embodiment 1 is only that the light source 3 and the movement mode of the spectrum receiving device 7 are different, see the following description for details:

[0087] see Figure 4 , ensure that the light output port of the light source 3 and the incident slit of the spectrum receiving device 7 are close to the blood bag 5, the modulation device 9 modulates the light source 3 so that it sends out a square wave light signal, the light source 3 transmits the blood sample in the blood bag 5, and the The spectrum receiving device 7 collects the transmission spectrum at the position a under the double optical path, namely: the position a and the position a'. The spectrum receiving device 7 is controlled by the displacement platform 6 to move to position b, and the transmission spectrum under the dual optical path at the acquisition position b is: the transmission spectrum at position b and position b'; the ...

Embodiment 3

[0092] During specific implementation, due to the limitation of the space structure, it may occur that the light source 3 and the spectrum receiving device 7 cannot be close to the blood bag 5. At this time, an optical fiber can be respectively arranged at the light source 3 and the spectrum receiving device 7 as the incident optical fiber 4 and outgoing fiber 8.

[0093] see Figure 5 , the modulation device 9 modulates the light source 3 to make it emit a square wave light signal, the light source 3 transmits the blood sample in the blood bag 5 through the incident optical fiber 4, and the spectrum receiving device 7 collects the transmission spectrum through the outgoing optical fiber 8, the incident optical fiber 4 and the outgoing optical fiber 8 respectively close to the blood bag 5, the incident optical fiber 4 is at the position a, and the light source 3 passes through the incident optical fiber 4 at this position under the double optical path, namely: position a and p...

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Abstract

The invention discloses a method for measuring the content of free hemoglobin by a double-optical-path multiposition modulating light source. The method includes clinging a light outlet of the light source and an entrance slit of a spectrum receiving device to a blood bag, modulating the light source by a modulation device, transmitting a blood sample by the light source, and collecting transmittance spectra by the spectrum receiving device; controlling the light source to move to different positions and changing optical path measurement by a displacement platform, transforming the transmittance spectra collected at multiple positions under the two optical paths into a frequency domain, creating intra-frequency-domain transmittance spectra, solving the logarithm of the ratio of the two intra-frequency-domain transmittance spectra at each position to acquire an absorption spectrum at the position, normalizing the absorption spectra at multiple positions, combining with chemical testing data and creating a mathematical model; collecting absorption spectra of an unknown blood sample at multiple positions according to the same method, and inputting the absorption spectra into the mathematical model after normalization to acquire the content of the free hemoglobin.

Description

technical field [0001] The invention relates to the field of chemical metering for concentration analysis of complex spectral solutions, in particular to a method for measuring free hemoglobin content with dual optical paths and multi-position modulated light sources. Background technique [0002] In the existing technology, the relatively mature technology is to detect the content of free hemoglobin in the blood bag through chemical testing, which has the outstanding advantage of high accuracy, but the way of chemical testing cannot meet the needs of fast, non-contact, and pollution-free. Due to its non-contact and non-polluting characteristics, it is also possible to detect the content of free hemoglobin in blood bags. [0003] In spectral detection, according to the Lambert-Beer law: the incident light intensity I of each wavelength is measured separately 0 and the outgoing light intensity I, the absorbance A of each wavelength is calculated by the formula (1). ∈ is the...

Claims

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Application Information

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IPC IPC(8): G01N21/31
CPCG01N21/31G01N21/255
Inventor 林凌王玉宇王艳军张盛昭罗永顺甄建芸李刚
Owner TIANJIN UNIV
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