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A package for an acidic dialysis fluid concentrate containing citrate and glucose

A technology of citrates, concentrates, applied in the field of systems for extracorporeal treatment, capable of addressing issues such as increased risk of systemic hemorrhage

Inactive Publication Date: 2017-12-05
GAMBRO LUNDIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for some patients, heparin infusion has disadvantages such as heparin-induced thrombocytopenia (HIT) and increased risk of systemic bleeding in the patient
However, the inclusion of glucose in acidic solutions is challenging due to the potential risk of the formation of glucose degradation products (GDP) such as 5-hydroxymethylfurfural (5-HMF)

Method used

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  • A package for an acidic dialysis fluid concentrate containing citrate and glucose
  • A package for an acidic dialysis fluid concentrate containing citrate and glucose
  • A package for an acidic dialysis fluid concentrate containing citrate and glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] A citrate-containing acid concentrate was prepared comprising:

[0097]

[0098] The pH of the concentrate was 2.1.

[0099] Acid concentrates are included in multilayer polyolefin membranes (Sealed Air M312A) in the package, the oxygen permeability of the package is 3.5g / m 2 / sky.

[0100] The acidic citrate-containing concentrate was then mixed with a source of bicarbonate (ie, a buffered solution containing bicarbonate at a concentration of 37 mM).

[0101] The pH of the final dialysis solution (at 37° C.) was estimated to be 7.22 (as a theoretical value, carbon dioxide formation is not taken into account).

Embodiment 2

[0103] A citrate-containing acid concentrate was prepared comprising:

[0104]

[0105] The pH of the concentrate was 2.2. The pH (at 37°C) of the final dialysate was estimated to be 7.25 (as a theoretical value).

Embodiment 3

[0107] A citrate-containing acidic concentrate comprising the following composition was prepared in the same manner as in Example 1:

[0108]

[0109] The pH of the concentrate was measured to be 2.3. The pH (at 37°C) of the final dialysate was estimated to be 7.28 (as a theoretical value).

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Abstract

The present invention concerns a package comprising an acidic citrate containing concentrate, an acidic citrate containing concentrate (or acidic citrate containing solution), and a system wherein the acidic citrate containing concentrate is included for providing a dialysis treatment. The acidic citrate containing concentrate contains citric acid and citrate in a molar ratio of 75:25 to 85:15, and has a pH of between 2 and 3.

Description

technical field [0001] The present invention relates to a package for citrate-containing acidic concentrates and solutions. The present invention also relates to a citrate-containing acidic concentrate, a citrate-containing acidic solution, and a method of using the citrate-containing acidic concentrate (or citrate-containing acidic solution) to treat blood in vitro processing system. Background of the invention [0002] There are a wide variety of extracorporeal blood treatments such as hemodialysis, hemofiltration and hemodiafiltration. They both use filters (also commonly called dialyzers). A conventional filter comprises first and second compartments separated by a membrane, the first compartment having an inlet and an outlet for blood circulation, and the second compartment having the outlet of the dialysis fluid). In case the treatment (eg hemodialysis) requires circulation of a treatment fluid (eg dialysis fluid), the second compartment also has an inlet. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61P7/08A61P7/02A61M1/16
CPCA61K31/194A61M1/16A61M1/3455A61M1/3672A61M2202/0486A61M2205/02A61M2205/0255A61M2230/208A61M1/1666A61M1/1668A61M1/3465A61K31/7004A61K33/10A61K33/14A61K33/00A61K33/06A61P7/02A61P7/08A61K2300/00A61M1/3621A61J1/1468A61J1/10A61J1/05
Inventor 胡萨姆·穆罕默德A·维斯兰德V·汉考克卡琳·桑丁O·卡尔松T·林登A·茨拉吉
Owner GAMBRO LUNDIA AB