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Safe and efficient gynecological washing and protection product and preparation method thereof

A technology for cleaning products and gynecology, applied in the field of chitosan derivative-based gynecological cleaning products and preparation thereof, can solve the problems of allergy, skin sensitivity, strong odor, etc., and achieve the effect of complete curative effect and difficult recurrence.

Active Publication Date: 2017-12-22
HAERBIN EN JOO BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these cleaning products use traditional Chinese medicine extracts as the main or auxiliary bactericidal ingredients, there is no problem of tolerance, but they generally have a strong smell when used. In addition, the skin of the vagina is sensitive, and traditional Chinese medicine will irritate the vagina. In severe cases, it may even cause cause allergies

Method used

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  • Safe and efficient gynecological washing and protection product and preparation method thereof
  • Safe and efficient gynecological washing and protection product and preparation method thereof
  • Safe and efficient gynecological washing and protection product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Prepare and synthesize the material described in formula (1) of the present invention:

[0092] Take by weighing 0.1 gram of chitosan and join in 100 milliliters of deionized water, mechanically stir at room temperature for half an hour, so that chitosan dissolves completely, thereby obtain the homogeneous solution that mass volume percent concentration is 0.1%; Slowly add thiourea trioxide into the system, the molar ratio of thiourea trioxide and chitosan is 10:1, the feeding time is 30 minutes, and the reaction at room temperature is kept for 60 minutes; A mixed solution of amino acid, N-hydroxysuccinimide (NHS) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl) (solvent: 30mmol / L of 2-(N-morpholino)ethanesulfonic acid (MES) buffer solution) 20ml was added to the above-mentioned reaction solution, and the stirring reaction was continued at room temperature for 48 hours, wherein chitosan, arginine, NHS, EDC The molar ratio of the solution is 50...

Embodiment 2

[0096] Prepare and synthesize the material described in formula (2) of the present invention:

[0097] Weigh 0.1g carboxymethyl chitosan (the number average molecular weight is 2×10 5 Da, the degree of carboxymethyl substitution is 100%, and the degree of deacetylation is 100%), add 100mL deionized water, and mechanically stir evenly at room temperature, so that carboxymethyl chitosan is completely dissolved, thereby obtaining a mass volume percent concentration of 0.1% solution; weigh 2,3-epoxypropyltrimethylammonium chloride, dissolve in 50mL deionized water, and stir mechanically at room temperature; Ammonium chloride solution was slowly added to the carboxymethyl chitosan solution in 3 times, and the feeding time was 4 hours, and then stirred at constant temperature for 4 hours; Adjust the pH value of the solution to 5.0 and the salt concentration to 0.01M to obtain solution S1; weigh NHS and EDC (molar ratio is 1:10), dissolve in 30mL 0.01M pH 5.0MES / HCl buffer solution ...

Embodiment 3

[0101] Prepare and synthesize the material described in formula (3) of the present invention:

[0102] Weigh 0.35g carboxymethyl chitosan (the number average molecular weight is 2×105Da, the degree of carboxymethyl substitution is 100%, and the degree of deacetylation is 95%), add 35mL deionized water, and stir mechanically at room temperature to make the carboxymethyl chitosan Polysaccharides were completely dissolved to obtain a solution with a concentration of 1% by mass volume; weighed NHS and EDC (molar ratio 1:1), dissolved in 15mL 0.01M pH5.0MES / HCl buffer solution to obtain a catalyst solution; weighed Add arginine to the catalyst solution for activation, and stir at room temperature for 1 hour; pour the arginine activation solution into the carboxymethyl chitosan solution for 3 times, and react for 24 hours under stirring at 45°C; Hydroxylamine hydrochloride with an equimolar ratio of arginine was added to the reaction solution to terminate the reaction; the reaction ...

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Abstract

The present invention discloses a safe and efficient gynecological washing and protection product and a preparation method thereof, wherein the safe and efficient gynecological washing and protection product comprises the following raw materials by weight: 0.01-5 parts of a chitosan derivative, 1-10 parts of a surfactant, 0.1-5 parts of vitamin E, 0.1-5 parts of vitamin B, 100 parts of sterilized deionized water, and a pH value regulator, wherein the pH value of the gynecological washing and protection product is adjusted to 4.3+ / -0.5. According to the present invention, the chitosan derivative-based gynecological washing and protection product can be used for various types of vaginitis, cervicitis, adnexitis, pelvic inflammatory diseases and other gynecological inflammations, has characteristics of complete treatment effect and no recurrence after cure, and further can be used as the care product for prevention of various venereal diseases and the assisted treatment product for patients with venereal diseases.

Description

technical field [0001] The present invention relates to the field of personal cleansing products. More specifically, it relates to a safe and efficient chitosan derivative-based gynecological care product and a preparation method thereof. Background technique [0002] Because women's reproductive organs are very different from men's, their structures are special and fragile, and they are more susceptible to infection and inflammation. Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue, and is a common disease in gynecology. Under normal circumstances, various flora in the female vagina restrict each other and live together to maintain the balance of the private parts. The female private parts present a natural weak acid environment with a physiological pH value of 3.8-4.4, thus having a natural defense function against the invasion of pathogens. When the natural defense function of the vagina is destroyed, pathogenic bacteria take the oppor...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P31/02A61P15/02A61P15/00C08B37/08A61K31/355
CPCA61K31/355A61K31/722C08B37/003A61K2300/00
Inventor 吕振东牛忠伟蒋士冬
Owner HAERBIN EN JOO BIOTECH CO LTD
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