Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ordered fiber scaffold loaded with gradient concentration bioactive molecules, preparation method and application

A technology of bioactive molecules and fiber scaffolds, applied in the field of biomedical materials, can solve the problems of unsatisfactory functional recovery of spinal cord injury, slow migration of NSCs, short retention time, etc., to achieve large-scale implementation, good stability, and simple preparation process controllable effect

Active Publication Date: 2020-05-19
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, naturally occurring SDF1α has a low concentration and short retention time at the injury site, resulting in slow migration of NSCs to the injury site and the inability to form sufficient colony-forming network connections, which is one of the reasons for the suboptimal functional recovery of spinal cord injuries.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ordered fiber scaffold loaded with gradient concentration bioactive molecules, preparation method and application
  • Ordered fiber scaffold loaded with gradient concentration bioactive molecules, preparation method and application
  • Ordered fiber scaffold loaded with gradient concentration bioactive molecules, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] Another aspect of the embodiments of the present invention provides a method for preparing an ordered fiber scaffold loaded with gradient concentrations of bioactive molecules, comprising:

[0048]An electrospinning device is provided, comprising a nozzle and a receiving device communicated with a spinning solution supply system, the nozzle and the receiving device are arranged at intervals, the receiving device includes a point electrode and a ring electrode, and the point electrode is arranged on the ring electrode at the center and corresponding to the nozzle setting;

[0049] Apply a voltage (preferably 8-12kV) between the nozzle and the receiving device, and use the nozzle to spray the spinning solution to the receiving device, so that the formed fibers are orderedly gathered on the receiving device, thereby Obtain the stent matrix;

[0050] And, the scaffold matrix is ​​loaded with bioactive molecules, and the bioactive molecules have collagen-specific binding re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an ordered fiber scaffold loaded with gradient concentration bioactive molecules, a preparation method and an application. The ordered fiber scaffold includes: a scaffold matrix mainly composed of a plurality of fibers, the fiber density at the center of the scaffold matrix is ​​greater than the fiber density at the periphery, and the fibers are mainly composed of collagen and high molecular polymers; and, The bioactive molecule loaded on the scaffold matrix has a collagen-specific binding region. The ordered fiber scaffold material may be a radial electrospinning material prepared by electrospinning technology. The ordered fiber scaffold material of the present invention can play an important role in the migration process of directional induced neural stem cells (NSCs), can significantly increase the migration number and migration distance of NSCs, and its preparation process is simple and controllable, economical and effective, and can be used in the treatment of spinal cord injury and other fields have broad application prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a bioactive molecule modified by a collagen-specific binding region carried by radial collagen fibers to form an ordered fiber scaffold containing bioactive molecules with continuous concentration gradients. Background technique [0002] Nerve-inducing scaffold materials have great application potential in the treatment of spinal cord injury. Orderly arranged nerve conduits provide structural support during the process of bridging gaps and inducing nerve growth. In addition, the stable gradient distribution of biological signals can provide a more favorable biological microenvironment for neural induced regeneration and functional connection. [0003] The application of nanofiber-induced materials prepared by electrospinning in the repair of spinal cord injury is far-reaching. Nano- to micron-scale fiber materials prepared by electrospinning technology can simulate the size an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24A61L27/18A61L27/54C12N5/0775C12N5/0797C12M3/00
CPCA61L27/18A61L27/24A61L27/54A61L2300/252A61L2300/426A61L2300/602C12M25/14C12N5/0623C12N5/0663C12N2533/30C12N2533/40C12N2533/54C08L89/00C08L67/04
Inventor 戴建武李晓然李梦媛孙杰
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com