Continuous complementary dual-gradient nanofiber bionic stent, and preparation method and application thereof

Abstract

The invention discloses a continuous complementary dual-gradient nanofiber bionic stent, and a preparation method and application thereof. The continuous complementary dual-gradient nanofiber bionic stent comprises a stent basal body, wherein the stent basal body comprises two fiber colonies which are arranged in parallel and are mutually crossed; in each fiber colony, the gather density gradientof fiber is reduced in the direction being gradually away from the center of the fiber colony; and the variation gradients of the fiber gather density in the two fiber colonies are complementary gradients. According to the continuous complementary dual-gradient nanofiber bionic stent disclosed by the invention, stent materials prepared for carrying dual-gradient active factors can be used for repairing damages in different tissue interfaces, and are used for simulating natural in vivo microenvironment to perform basic research or drug screening; and besides, the stent materials for dual-gradient cells can be prepared for repairing damages in different tissue interfaces; the continuous complementary dual-gradient nanofiber bionic stent is used for simulating natural in vivo cell distribution and researching intercellular interaction, and is wide in application prospect; and the preparation technology is simple and controllable, so that scaled implementation is facilitated.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a continuous complementary double-gradient nanofiber bionic scaffold and a preparation method thereof, as well as its application in preparing a scaffold material carrying dual-gradient active factors or dual-gradient cells. Background technique [0002] Gradient active factors play an important role in embryogenesis and development, tissue repair and regeneration, wound healing, etc. In particular, there are two complementary double-gradient active factors or cells at certain specific positions. For example, during the development of the central nervous system, there is a concentration gradient of bone morphogenetic protein (BMP2) along the dorsal-ventral axis of the spinal cord, and a concentration gradient of sonic hedgehog (Shh) along the ventral-dorsal axis of the spinal cord; at different tissue interfaces such as bone and At the interface of cartilage, bone and tendon, o...

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Problems solved by technology

But only suitable for continuous single-gradient nanofiber scaffold preparation

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