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Novel applications and preparation method of traditional Chinese medicinal composition containing extracts of herba artemisiae scopariae, fructus gardeniae and radix scutellariae

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of insufficient safety evidence and clinical application limitations of weight loss drugs, and achieve the effect of comprehensive effect and blood lipid reduction

Inactive Publication Date: 2018-01-12
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some researchers pointed out that the safety evidence of the two weight-loss drugs lorcaserin and phentermine / topiramate launched in the United States in 2012 is insufficient, and there are still many unresolved issues in terms of benefits / risks
For the surgical treatment of obesity, although the curative effect is exact, its clinical application is greatly limited due to its trauma, postoperative complications and even the risk of death.

Method used

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  • Novel applications and preparation method of traditional Chinese medicinal composition containing extracts of herba artemisiae scopariae, fructus gardeniae and radix scutellariae
  • Novel applications and preparation method of traditional Chinese medicinal composition containing extracts of herba artemisiae scopariae, fructus gardeniae and radix scutellariae
  • Novel applications and preparation method of traditional Chinese medicinal composition containing extracts of herba artemisiae scopariae, fructus gardeniae and radix scutellariae

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] The preparation of embodiment 1 Yinzhihuang Granules

[0111] 1) Preparation of capillary extract: take 100.00 kg capillary, decoct three times with water, 1.5 hours for the first time, 1 hour for the second and third times, combine the decoctions, filter, and concentrate the filtrate to a relative density of 70°C Add ethanol to make the alcohol content reach 70%, refrigerate for 24 hours, filter, recover the ethanol from the filtrate and concentrate it to 70°C when the relative density is 1.14, add ethanol to make the alcohol content reach 85%, refrigerate for 24 hours, filter , the filtrate recovered ethanol and concentrated to 70 DEG C when the relative density was 1.20, then added 5 times the amount of water, refrigerated for 48 hours, filtered, the filtrate was concentrated into a thick paste with a relative density of 1.30 at 70 DEG C, vacuum dried, and pulverized to obtain capillary extract 7.28kg;

[0112] 2) Preparation of gardenia extract: take 100.00 kg of g...

Embodiment 2

[0116] The preparation of embodiment 2 Yinzhihuang granules

[0117] 0.120kg of capillary extract, 0.050kg of gardenia extract, 0.455kg of scutellaria baicalensis extract and 0.060kg of honeysuckle extract obtained in Example 1 were ground into fine powder, added 5.00kg of sucrose powder and 4.315kg of dextrin, mixed evenly, and prepared Granulated, dried, made into 10.00kg, packaged, ready to be obtained.

Embodiment 3

[0118] The preparation of embodiment 3 Yinzhihuang granules

[0119] 0.300kg of capillary extract, 0.150kg of gardenia extract, 1.024kg of scutellaria baicalensis extract and 0.200kg of honeysuckle extract obtained in Example 1 were ground into fine powder, added 5.000kg of sucrose powder and 3.326kg of dextrin, mixed evenly, and prepared Granulated, dried, made into 10.00kg, packaged, ready to be obtained.

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Abstract

The invention provides novel applications and a preparation method of a traditional Chinese medicinal composition containing extracts of herba artemisiae scopariae, fructus gardeniae and radix scutellariae. The invention relates to the traditional Chinese medicinal composition for treating obesity and applications of the traditional Chinese medicinal composition, belonging to the field of medicines. The traditional Chinese medicinal composition is prepared from the following raw medicinal materials in parts by weight: 12-30 parts of extract of herba artemisiae scopariae, 5-15 parts of extractof fructus gardeniae, 40-90 parts of extract of radix scutellariae (calculated in terms of baicalin), and 6-20 parts of extract of honeysuckle flowers. The pharmacodynamic experiment proves that the composition can obviously reduce the body weight, TCH, TG and HDL-C of nutritional obesity rats, and obviously reduce the fat index and fat number of the nutritional obesity rats and reduce the size ofadipocytes, thus having the obvious effects of losing weight and lowering lipid. The traditional Chinese medicinal composition provided by the invention is comprehensive in effects when used for treating obesity, the body weight, body fat and blood fat are obviously reduced, in addition, the toxic and side effects are low, the safety is good, and thus the traditional Chinese medicinal compositionhas the broad market prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and a new application, in particular to a traditional Chinese medicine composition for treating obesity, a preparation method and a new application, and belongs to the field of medicine. Background technique [0002] CN1616012A discloses a traditional Chinese medicine composition, which is composed of capillary extract, gardenia extract, scutellaria baicalensis extract and honeysuckle extract. Acute, chronic hepatitis and severe hepatitis (type I) caused by evil internal accumulation can also be used for comprehensive treatment of other types of severe hepatitis. The name of the drug of the present invention is Yinzhihuang Granules, the approval number is Z20030028; or Yinzhihuang Tablets, the approval number is Z20050121. Both medicines are Chinese patent medicines of Lunan Houpu Pharmaceutical Co., Ltd. CN1709436A discloses a kind of Yinzhihuang buccal tablet ...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P3/04A61P3/06A61P1/16A61P31/20A61P31/14
Inventor 张贵民苏瑞强李蔚群
Owner LUNAN PHARMA GROUP CORPORATION
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