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Application of 1.6-hexanediol or its derivative in preparation of antitumor drug
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A technology of anti-tumor drugs and derivatives, which is applied in the field of anti-tumor drugs and achieves good application prospects
Active Publication Date: 2018-01-26
海安百优基质生物工程有限公司
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Whether the malignant transformation of tumor cells is achieved through excessive or abnormal liquid phase separation, and whether the development of new anti-tumor drugs can be based on inhibiting the liquid phaseseparation process as a starting point, but there is no report in this regard in the prior art
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[0036] Normal pancreatic epithelial cell line HPDE6-C7, pancreatic c...
Embodiment 2
[0047] Referring to Example 1, lung cancer cells H2087 and melanoma cells B16 (supplied by Shanghai Yubo Biotechnology Co., Ltd.) were treated with different concentrations of 1,6-hexanediol, and the number of viable cells was detected using CCK-8.
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Abstract
The invention discloses an application of 1.6-hexanediol or its derivative in preparation of an antitumor drug. The 1.6-hexanediol or its derivative can destroy weak interaction of protein, inhibits aliquid-phase separating process, and can effectively inhibit the generation and development of tumor. The 1.6-hexanediol can relatively and specifically inhibit the cell proliferation of pancreascancer, lungcancer and melanoma under low concentration condition, and has good application prospect on preparation of the antitumor drugs for treating pancreascancer, lung cancer and melanoma.
Description
technical field [0001] The invention relates to the technical field of antitumor drugs, in particular to the application of 1,6-hexanediol or its derivatives in the preparation of antitumor drugs. Background technique [0002] 1,6-Hexanediol, the English name is 1,6-hexanediol, the structural formula is: As an important fine chemical material, 1,6-hexanediol is widely used in polyurethane, polyester, coil coating, light curing agent and other fields. In addition, due to its certain permeability, 1,6-hexanediol can also be used in cosmetic active ingredients and topical pharmaceutical compositions for skin diseases, but its application in antitumor drugs has not been reported. [0003] Pancreatic cancer (pancreatic cancer) is a kind of digestive tract tumor, and 95% of pancreatic cancers are pancreatic ductal cellcarcinoma (pancreatic ductal adenocarcinoma, PDAC). Although the incidence of pancreatic cancer is relatively low, pancreatic cancer is the fourth leading cause ...
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Application Information
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