Drive method of independent electrodes on medium electrowetting digital microfluidic chip
A microfluidic chip, driving method technology, applied in fluid controllers, chemical instruments and methods, laboratory containers, etc., can solve the problems of not conforming to the laboratory on a chip, lack of control flexibility, etc.
Active Publication Date: 2018-02-02
FUDAN UNIV
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Problems solved by technology
Existing technologies, such as direct drive, cross drive of upper and lower plates, broadcast drive, active thin film transistor auxiliary drive, etc., either require more complicated external equipment and specific processes, or lack control flexibility
These deficiencies obviously do not meet the integration, portability and cheapness of lab-on-a-chip
Method used
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[0058] Such as Figure 1 to Figure 4 As shown, the droplet driving system based on the dielectric electrowetting digital microfluidic chip in the present invention mainly includes: a dielectric electrowetting digital microfluidic chip (hereinafter referred to as the microfluidic chip 4), a single-chip microcomputer 7, an AND gate Array 15, solid state relay array 10, personal computer 18.
[0059] The microfluidic chip 4 ( Figure 4 ), based on the PCB plug-hole substrate, which contains 100 electrodes that can be independently controlled, and is the main component of the digital microfluidic experiment of dielectric electrowetting; the through holes around the electrode array are lead areas, which are used to connect the independent electrodes Connect with external control circuit. The single-chip microcomputer 7 is, for example, an ATmega2560 micro-control board, which is used to drive the droplets on the microfluidic chip 4, communicate with the personal computer 18, and ...
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The invention relates to a drive method of independent electrodes on a medium electrowetting digital microfluidic chip. The method includes: a personal computer transmits a first instruction to a single-chip microcomputer so as to control a drive system to power up the electrodes on the medium electrowetting digital microfluidic chip one by one; the personal computer distinguishes whether currentdrive droplets or the obstacles of the droplets exist on the electrodes or not according to a detection value formed by the detecting result obtained by a single-chip microcomputer detecting circuit detecting the microfluidic chip, the sizes and positions of the current drive droplets and the obstacles of the droplets on the electrodes are characterized, and the routes of the current drive droplets from appointed starting positions to appointed destination positions are planned and displayed; the personal computer transmits a second instruction with route related information to the single-chipmicrocomputer to control the drive system to sequentially power up the electrodes, distributed along the routes, on the microfluidic chip so as to allow the current drive droplets to move along the routes. By the method, the drive of one or more droplets can be controlled flexibly.
Description
technical field [0001] The invention relates to microfluidic chip technology, in particular to a driving method for independent electrodes on a dielectric electrowetting digital microfluidic chip. Background technique [0002] Microfluidic chip is a potential technology to realize Lab-on-a-chip (Lab-on-a-chip), which can integrate basic operation units such as sample preparation, reaction, separation and detection in the process of biological, chemical and medical analysis into a micron chip. On a micro-scale chip, a network of micro-channels is formed, and a controllable fluid runs through the entire system to replace various functions of a conventional biological or chemical laboratory and automatically complete the entire process of analysis. Due to its great potential in integration, automation, portability and high efficiency, microfluidic chip technology has become a current research hotspot and one of the world's cutting-edge technologies. [0003] The advantage of t...
Claims
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Patent Timeline
Login to View More IPC IPC(8): B01L3/00
CPCB01L3/50273B01L3/502784B01L3/502792B01L2200/0636B01L2400/0427
Inventor 李春桥周嘉
Owner FUDAN UNIV