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Il-18 Binding Protein (Il-18bp) And Antibodies In Inflammatory Diseases

A 1. IL-18, antibody technology, applied in allergic diseases, antibodies, anti-inflammatory agents, etc., can solve problems such as excessive secretion of constitutive IL-18

Pending Publication Date: 2018-02-02
AB2 BIO
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

NLRC4 mutations also lead to constitutive IL-18 hypersecretion

Method used

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  • Il-18 Binding Protein (Il-18bp) And Antibodies In Inflammatory Diseases
  • Il-18 Binding Protein (Il-18bp) And Antibodies In Inflammatory Diseases
  • Il-18 Binding Protein (Il-18bp) And Antibodies In Inflammatory Diseases

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Experimental program
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Effect test

Embodiment

[1117] a. Detection of free IL-18vs. complex IL-18 / IL-18BP

[1118] 1. Common detection of IL-18 in patients

[1119]Quantification of human IL-18 in patients was performed with an ELISA assay detecting total IL-18 (both free form and IL-18BP complex). This ELISA contained commercially available antibodies (see Table 1 below). The most common ELISA assay is performed with anti-IL-18 antibody pairs developed by Taniguchi et al. 1997 and sold by different suppliers, namely mouse mAb 125-2H as primary / capture antibody and rat mAb 159-12B As a secondary / chromogenic antibody.

[1120]

[1121]

[1122] 2. Estimation of Free IL-18 Levels

[1123] To date, there are no reports of measured levels of free IL-18. Free IL-18 estimates were made by extrapolation using the calculations described by Novick et al. 2004 (see below). The data compare the levels of IL-18 and IL-18BP in humans. In these studies, investigators used commercial monoclonal anti-IL-18 antibody 125-2H an...

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Abstract

The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders, in particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.

Description

technical field [0001] The present invention provides means and methods for the treatment of interleukin 18 (IL-18) related diseases and conditions, in particular means and methods for the treatment of Still's disease. In particular, the present invention discloses antibodies and IL-18 binding proteins (IL-18BP) that specifically bind free IL-18 for use in such therapy, and in assays for the quantification of free IL-18 in body fluids. Background technique [0002] Interleukin-18 (IL-18), also known as interferon-gamma inducible factor, is a cytokine produced by activated macrophages, Kupffer cells and other cells. IL-18 binds to the IL-18 receptor and induces cell-mediated immunity. Deficiency (eg, knockout) of the IL-18 cytokine receptor or IL-18 cytokine results in impaired natural killer (NK) cell activity and TH1 responses. In addition to its physiological role, IL-18 can also cause severe inflammatory diseases. For the purpose of early diagnosis of such disorders, i...

Claims

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Application Information

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IPC IPC(8): A61K39/395C07K16/24G01N33/68A61P11/00A61P19/02A61P29/00A61P1/00A61P35/02
CPCC07K16/244G01N33/6869G01N2333/54A61K2039/505C07K2317/30C07K2317/92C07K2317/76A61K38/1709A61K2039/545A61P1/00A61P1/04A61P11/00A61P17/00A61P19/02A61P19/06A61P27/02A61P27/06A61P29/00A61P35/02A61P37/02A61P43/00A61P7/00A61P9/00A61P9/04A61P3/10A61K39/00A61K39/395
Inventor G·德尔瓦尔E·席夫林
Owner AB2 BIO
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