Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine composition for improving safety of compound radix angelicae sinensis injection solution

A technology of composition and injection, which is applied in the field of medicine, and achieves the effect of obvious dissolution aid, improved safety, and low dosage

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound angelica injection produced in China also adds phenoxyethanol as a co-solvent, facing the same problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine composition for improving safety of compound radix angelicae sinensis injection solution
  • Medicine composition for improving safety of compound radix angelicae sinensis injection solution
  • Medicine composition for improving safety of compound radix angelicae sinensis injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016] Preparation method: decoct angelica and astragali with water twice, each time for 2 hours, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C), a...

Embodiment 2

[0018]

[0019] Preparation method: decoct angelica and astragali with water twice, each time for 2 hours, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C), a...

Embodiment 3

[0021]

[0022] Preparation method: decoct angelica and astragali with water twice, each time for 2 hours, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; Panax notoginseng is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, add Ethanol so that the ethanol content is 65%, let stand overnight, filter, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (80°C), a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pharmaceutical composition for improving the safety of compound angelica injection. The pharmaceutical composition is a pharmaceutical composition for injection mainly made of angelica extract, astragalus extract, notoginseng extract and methyl methacrylate. The present invention adopts the co-solvent with better safety and more obvious solubilizing effect to replace the co-solvent phenoxyethanol which has potential safety hazards and affects product quality in the compound angelica injection, and the safety of methyl methacrylate is higher than that of phenoxyethanol. The dosage is lower, reducing the probability and risk of adverse drug reactions, and improving the safety of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition for improving the safety of compound angelica injection. Background technique [0002] The standard of compound angelica injection is recorded in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine), and the raw materials are angelica, astragalus, and notoginseng, which belong to traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Angelica Injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical app...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/19A61K9/08A61K47/14A61P15/00A61P29/00
CPCA61K36/481A61K9/0019A61K9/08A61K9/19A61K36/232A61K36/258A61K47/14A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com