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Intravascular stent

A technology of vascular stents and seeds, applied in the field of vascular stents, can solve the problems of affecting drug efficacy, slow release, and drug effect effects, and achieve the effects of prolonging release time, improving release efficiency, good biocompatibility and degradability

Inactive Publication Date: 2018-02-09
成都测迪森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polylactic acid, polyglycolic acid, etc. are water-insoluble, and the cross-linked drug molecules are released slowly in the body, which affects the efficacy of the drug.
Polyglutamic acid, etc. are too water-absorbing and easy to disintegrate, which also affects its efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0020] Specific embodiment 1: a kind of cyclodextrin graft modified polymalic acid, the preparation step is as follows:

[0021] Step 1. Inoculate the polymalic acid strain on a plate, culture it at 25°C for 2 hours, and pick a single colony for activation;

[0022] Step 2, seed cultivation, inoculating the above-mentioned activated bacteria into the seed medium, the cultivation temperature is 26°C, the rotation speed is 300 rpm, and the cultivation time is 48 hours;

[0023] Step 3, expanding the culture, culturing the seed solution in the expanding medium according to the inoculum amount of 10%, the temperature is 26°C, the rotation speed is 300 rpm, and the culture time is 72 hours;

[0024] Step 4, inoculate the expanded culture solution into the fermenter according to the inoculum amount of 5% for cultivation, the cultivation temperature is 30°C, the cultivation time is 10 days, and the fermentation speed is 300 rpm;

[0025] Step 5, take the fermentation broth, collect ...

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Abstract

The invention discloses a blood vessel stent, which comprises a carbon alloy body stent and a coating material, wherein the coating material is cyclodextrin grafted polymalic acid.

Description

technical field [0001] The invention relates to a blood vessel stent. Background technique [0002] Cardiac stent (Stent), also known as coronary stent, is a medical device commonly used in cardiac interventional surgery and has the function of dredging arteries. The main materials are stainless steel, nickel-titanium alloy or cobalt-chromium alloy. [0003] Existing metal stents easily lead to restenosis of blood vessels. In a new type of stent, anti-thrombotic and anti-proliferative drugs are wrapped on the heart stent. After the stent is implanted, the drug is released slowly, which can increase the local drug concentration, reduce side effects, and reduce the rate of restenosis. [0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In biodegradable polymer materials, the drug release rate is low and the effective time is short. The commonly used degradable material carriers include polylactic acid, polyglycolic acid, etc...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/02A61L31/10C12P7/62C08G81/00
CPCA61L31/16A61L31/024A61L31/10A61L2300/216A61L2300/602C08G81/00C12P7/625C08L87/005
Inventor 郑浩
Owner 成都测迪森生物科技有限公司
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