Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof

A polysalicylic acid, bioactive technology, applied in the direction of organic active ingredients, drug combinations, pharmaceutical formulations, etc., can solve problems such as unfavorable clinical applications, complex multi-component compositions, etc. The effect of preventing damage to the skin

Active Publication Date: 2021-04-30
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the reported multifunctional hydrogels have complex multi-component compositions, which are not conducive to clinical appli

Method used

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  • Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof
  • Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof
  • Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof

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Example Embodiment

[0033]The present invention is dedicated to preparing a good biocompatibility and functional properties, biocompatibility, ultraviolet shielding properties, and antioxidant properties. The preparation method includes the following steps:

[0034]1) Preparation of PSA polymer: Solubidate (SA) was dissolved in dichloromethane, reacted as a catalyst as a catalyst as a catalyst in dichloride, and obtained as follows:

[0035]

[0036]2) FPSA polymer preparation: The above-described synthetic PSA polymer and formoylated Posa Polymer (F127-TS) dissolved N, N-dimethylformamide, with K2CO3The reaction is carried out as a catalyst to obtain an FPSA polymer, and the structural formula is as follows:

[0037]

[0038]3) FPSA hydrogel preparation: The FPSA polymer synthesized by an appeal is dissolved in deionized water at a mass fraction of 20 to 50%, and stirred at this temperature for 2 to 5 hours, so that the FPSA is completely dissolved. In deionized water, the stirring ends at room temperature to obtain...

Example Embodiment

[0040]Example 1

[0041]1) Preparation of PSA polymer: dissolved 10 mmol salicylic acid monomer in dried dichloromethane, was added to 10 mmol of dried dichloride room temperature for 5 min, and 10 mmol of dried pyridine was added at 30 ° C for 12 h, and finally The product was extracted with 10% dilute hydrochloric acid (3 * 100 mL), washed with saturated saline, and finally rotated to obtain a polymer.

[0042]2) FPSA polymer preparation: The above-described formal formylated poloxham polymer (F127-TS) and PSA polymers were dissolved in molar ratio 1: 2 in DMF, and finally added F127-TS polymer and K.2CO3The molar ratio 1: 3 as a catalyst, reacted at 80 ° C for 36 h, and the final product was purified, and then dried to give a polymer.

[0043]3) FPSA hydrogel preparation: The FPSA polymer synthesized by the appeal was carried out in a deionized water at a mass fraction of 20%, and stirred at this temperature for 3 h, so that the FPSA was completely dissolved in deionized water, and the mi...

Example Embodiment

[0044]Example 2

[0045]1) Preparation of PSA polymer: The 10 mmol salicylic acid monomer was dissolved in dried dichloromethane, and 20 mmol of dried dichloride is added to stir for 5 min, and 20 mmol dried pyridine is added at 3 ° C for 12 h, and finally The product was extracted with 10% dilute hydrochloric acid (3 * 100 mL), washed with saturated saline, and finally rotated to obtain a polymer.

[0046]2) FPSA polymer preparation: The above-described formal formylated poloxham polymer (F127-TS) and PSA polymers were dissolved in molar ratio 1: 2 in DMF, and finally added F127-TS polymer and K.2CO3The molar ratio 1: 3 as a catalyst, reacted at 80 ° C for 36 h, and the final product was purified, and then dried to give a polymer.

[0047]3) FPSA hydrogel preparation: The FPSA polymer synthesized by the appeal was carried out in a deionized water at a mass fraction of 20%, and stirred at this temperature for 3 h, so that the FPSA was completely dissolved in deionized water, and the mixture ...

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Abstract

The invention discloses bioactive antioxidant polysalicylic acid hydrogel as well as a preparation method and theapplication thereof. The method comprises the following steps: (1) preparing a PSa polymer; (2) preparing an FPSa polymer; and (3) preparing FPSa hydrogel. and 4) characterizing the physical and chemical properties of the FPSa hydrogel and performing biological application. The FPSa polymer has good biocompatibility and degradability, the synthesis method of polymerization reaction and catalytic reaction is environment-friendly, the operation is simple, and the raw material cost is low. The FPSa hydrogel has good ultraviolet shielding performance and can prevent ultraviolet rays from damaging the skin. The result shows that the FPSa hydrogel has important potential application value in the aspect of preventing skin light damage, and a strategy for designing multifunctional single-part bioactive hydrogel is provided for biomedical application.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a bioactive anti-oxidation polysalicylic acid hydrogel and a preparation method and application thereof. Background technique [0002] Biomedical hydrogels have been used as effective scaffolds or matrices in biomedical applications, including drug delivery systems and tissue engineering. Hydrogels have a 3D network structure, which offers potential applications for bioactive molecule or drug delivery. In addition, the hydrogel provided a moist microenvironment that promoted cell proliferation and differentiation to enhance tissue regeneration. So far, various hydrogels including polysaccharides / polyesters / proteins / polyethers / nanocomposites have been developed for biomedical applications. To meet the urgent needs of regenerative medicine, multifunctional hydrogels such as injectable / self-healing / temperature-responsive / antioxidative properties...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/765A61K47/60A61P17/16C08J3/075C08G81/00C08L87/00
CPCA61K31/765A61K9/06A61K47/60A61P17/16C08J3/075C08G81/00C08J2387/00
Inventor 雷波杨玉连王敏
Owner XI AN JIAOTONG UNIV
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