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Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof

A polysalicylic acid, bioactive technology, applied in the direction of organic active ingredients, drug combinations, pharmaceutical formulations, etc., can solve problems such as unfavorable clinical applications, complex multi-component compositions, etc. The effect of preventing damage to the skin

Active Publication Date: 2021-04-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the reported multifunctional hydrogels have complex multi-component compositions, which are not conducive to clinical applications, so the development of bioactive thermosensitive hydrogels with similar compositions is highly necessary for biomedical applications

Method used

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  • Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof
  • Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof
  • Bioactive antioxidant polysalicylic acid hydrogel as well as preparation method and application thereof

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preparation example Construction

[0033] The present invention is committed to preparing a biocompatibility and functional properties, biocompatibility, ultraviolet shielding performance and anti-oxidation performance. The preparation method comprises the following steps:

[0034] 1) Preparation of PSa polymer: Dissolving salicylic acid (Sa) in dichloromethane, reacting with thionyl chloride and pyridine as a catalyst to obtain PSa polymer, the structural formula is as follows:

[0035]

[0036] 2) Preparation of FPSa polymer: dissolve the above-mentioned synthesized PSa polymer and formylated poloxamer polymer (F127-Ts) in N,N-dimethylformamide, and use K 2 CO 3 React as catalyst, obtain FPSa polymer, structural formula is as follows:

[0037]

[0038] 3) Preparation of FPSa hydrogel: dissolve the FPSa polymer synthesized by the appeal in deionized water with a mass fraction of 20-50% at 0-10°C, and stir at this temperature for 2-5 hours to completely dissolve FPSa in In deionized water, after stirri...

Embodiment 1

[0041] 1) Preparation of PSa polymer: Dissolve 10 mmol of salicylic acid monomer in dry dichloromethane, add 10 mmol of dry thionyl chloride and stir at room temperature for 5 min, then add 10 mmol of dry pyridine and react at 30°C for 12 h, finally The product was extracted with 10% dilute hydrochloric acid (3*100 mL), washed with saturated brine, and finally rotated to obtain a polymer.

[0042] 2) Preparation of FPSa polymer: dissolve the formylated poloxamer polymer (F127-Ts) and PSa polymer synthesized above in DMF at a molar ratio of 1:2, and finally add F127-Ts polymer and K 2 CO 3 The molar ratio of 1:3 was used as a catalyst, and the reaction was carried out at 80°C for 36 hours. The final product was purified by dialysis and freeze-dried to obtain a polymer.

[0043] 3) Preparation of FPSa hydrogel: Dissolve the FPSa polymer synthesized above in deionized water at 4°C with a mass fraction of 20%, and stir at this temperature for 3 hours to completely dissolve FPSa i...

Embodiment 2

[0045]1) Preparation of PSa polymer: Dissolve 10 mmol of salicylic acid monomer in dry dichloromethane, add 20 mmol of dry thionyl chloride and stir at room temperature for 5 min, then add 20 mmol of dry pyridine and react at 3°C ​​for 12 h, finally The product was extracted with 10% dilute hydrochloric acid (3*100 mL), washed with saturated brine, and finally rotated to obtain a polymer.

[0046] 2) Preparation of FPSa polymer: dissolve the formylated poloxamer polymer (F127-Ts) and PSa polymer synthesized above in DMF at a molar ratio of 1:2, and finally add F127-Ts polymer and K 2 CO 3 The molar ratio of 1:3 was used as a catalyst, and the reaction was carried out at 80°C for 36 hours. The final product was purified by dialysis and freeze-dried to obtain a polymer.

[0047] 3) Preparation of FPSa hydrogel: Dissolve the FPSa polymer synthesized above in deionized water at 4°C with a mass fraction of 20%, and stir at this temperature for 3 hours to completely dissolve FPSa i...

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Abstract

The invention discloses bioactive antioxidant polysalicylic acid hydrogel as well as a preparation method and theapplication thereof. The method comprises the following steps: (1) preparing a PSa polymer; (2) preparing an FPSa polymer; and (3) preparing FPSa hydrogel. and 4) characterizing the physical and chemical properties of the FPSa hydrogel and performing biological application. The FPSa polymer has good biocompatibility and degradability, the synthesis method of polymerization reaction and catalytic reaction is environment-friendly, the operation is simple, and the raw material cost is low. The FPSa hydrogel has good ultraviolet shielding performance and can prevent ultraviolet rays from damaging the skin. The result shows that the FPSa hydrogel has important potential application value in the aspect of preventing skin light damage, and a strategy for designing multifunctional single-part bioactive hydrogel is provided for biomedical application.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a bioactive anti-oxidation polysalicylic acid hydrogel and a preparation method and application thereof. Background technique [0002] Biomedical hydrogels have been used as effective scaffolds or matrices in biomedical applications, including drug delivery systems and tissue engineering. Hydrogels have a 3D network structure, which offers potential applications for bioactive molecule or drug delivery. In addition, the hydrogel provided a moist microenvironment that promoted cell proliferation and differentiation to enhance tissue regeneration. So far, various hydrogels including polysaccharides / polyesters / proteins / polyethers / nanocomposites have been developed for biomedical applications. To meet the urgent needs of regenerative medicine, multifunctional hydrogels such as injectable / self-healing / temperature-responsive / antioxidative properties...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/765A61K47/60A61P17/16C08J3/075C08G81/00C08L87/00
CPCA61K31/765A61K9/06A61K47/60A61P17/16C08J3/075C08G81/00C08J2387/00
Inventor 雷波杨玉连王敏
Owner XI AN JIAOTONG UNIV
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