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Trap Fill Time Dynamic Range Enhancement

A time-segment, first-time technology applied in the field of mass and/or ion mobility spectrometry, which can solve complex calibration, mass and/or charge discrimination, etc., to achieve the effect of enhanced dynamic range

Active Publication Date: 2020-03-06
MICROMASS UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While this produces the desired continuous ion beam, it can also result in undesired mass and / or charge discrimination, necessitating complex calibration

Method used

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  • Trap Fill Time Dynamic Range Enhancement
  • Trap Fill Time Dynamic Range Enhancement
  • Trap Fill Time Dynamic Range Enhancement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0238] According to various embodiments, a substantially continuous ion beam is generated. Can be, for example, by ionizing a sample (e.g., using an ion source) and / or by ionizing a sample to generate parent or precursor ions and then fragmenting or chemically reacting the parent or precursor ions (e.g., using a fragmentation, collision, or reaction device) To generate ions and the like, an ion beam is generated.

[0239] The first set of ions is effectively formed by accumulating ions from the ion beam for a first continuous time period T1. A second set of ions may then be effectively formed by accumulating ions from the ion beam for a second continuous time period T2. Ions may accumulate in an ion trap or an ion accumulation region, such as a mass-selective or non-mass-selective ion trap or an accumulation region of an ion mobility separation device.

[0240] The second continuous time period T2 may be substantially less than the first continuous time period T1 (ie, the fi...

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Abstract

A method of mass and / or ion mobility spectrometry is disclosed, the method comprising accumulating ions one or more times during a first time period (T1) to form one or more first ion groups, and during a second time period (T2 ) to accumulate ions one or more times in order to form one or more second ion groups, wherein the second time period (T2) is less than the first time period (T1), one or more first ion groups are analyzed to generate one or more a first data set, analyze one or more second ion groups to generate one or more second data sets, and determine whether the one or more first data sets include saturated and / or distorted data. If it is determined that the one or more first data sets include saturated and / or distorted data, the method further includes replacing the saturated and / or distorted data from the one or more second data sets with corresponding data from the one or more second data sets. / or distorted data.

Description

technical field [0001] The present invention relates generally to mass and / or ion mobility spectrometry, and in particular to mass and / or ion mobility spectrometers and methods of mass and / or ion mobility spectrometry. Background technique [0002] It is known to use the method of transmission switching to extend the dynamic range of an orthogonal time-of-flight mass spectrometer. The original continuous ion beam is repeatedly switched between high and low transmission modes by attenuating the beam. Mass spectra are acquired continuously and repeatedly during high transmission mode and low transmission mode. [0003] Individual mass spectral peaks in high transmission mode spectra distorted by exceeding the dynamic range of the detection system are replaced by corresponding data from low transmission mode spectra (scaled by an appropriate factor) where detector saturation has not yet occurred. Composite spectra produced in this way have increased dynamic range. [0004] U...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/00H01J49/02H01J49/42
CPCH01J49/0031H01J49/0036H01J49/025H01J49/4265H01J49/0027H01J49/06
Inventor 马丁·雷蒙德·格林詹森·李·维尔德古斯史蒂文·德里克·普林格尔凯文·R·豪斯
Owner MICROMASS UK LTD