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Application of endoplasmic reticulum Ca<2+> blocking agent in preparation of drugs for treating arsenic poisoning of cranial nerves

A blocking agent, endoplasmic reticulum technology, applied in the field of medicine, can solve the problem of less arsenic staining of brain nerves, achieve strong theoretical and practical significance, and reduce the effect of arsenic toxicity

Inactive Publication Date: 2018-02-23
姜玉峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few effective studies on how to reduce arsenic exposure in the cranial nerves

Method used

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  • Application of endoplasmic reticulum Ca&lt;2+&gt; blocking agent in preparation of drugs for treating arsenic poisoning of cranial nerves
  • Application of endoplasmic reticulum Ca&lt;2+&gt; blocking agent in preparation of drugs for treating arsenic poisoning of cranial nerves
  • Application of endoplasmic reticulum Ca&lt;2+&gt; blocking agent in preparation of drugs for treating arsenic poisoning of cranial nerves

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The main experimental instruments are listed in Table 2.

[0063] Table 2. Description of Experimental Instruments

[0064]

[0065]

[0066] The main experimental reagents are listed in Table 3.

[0067] Table 3. Description of experimental reagents

[0068]

[0069]

[0070] Experimental animals: 32 12-week-old SPF grade male Sprague-Dawley (SD) rats (production license SCXK (new) 2011-0004 provided by the Animal Experiment Center of the First Affiliated Hospital of Xinjiang Medical University) were selected, and the breeding environment simulated natural day and night conditions , temperature (21 ± 2) ℃, humidity 40% to 60%.

[0071] Main solution preparation:

[0072] (1)NaAsO 2 Solution preparation: use an electronic scale to accurately weigh 0.1299g NaAsO 2 (purity ≥ 98%) powder, the operation needs to be carried out in a sterile ultra-clean bench, take 10ml double distilled water to dissolve NaAsO 2 powder, because it is easily soluble in water,...

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Abstract

The invention discloses application of an endoplasmic reticulum Ca<2+> blocking agent in the preparation of drugs for treating arsenic poisoning of cranial nerves, relating to the technical field of medicines. The endoplasmic reticulum Ca<2+> blocking agent is dantrolene and / or 2-aminoethyl diphenylboronic acid and is capable of alleviating or improving arsenic-infected toxicity of the cranial nerves, and a new way is provided for the treatment of the arsenic poisoning of the cranial nerves.

Description

technical field [0001] The invention relates to the field of medicine, in particular to endoplasmic reticulum Ca 2+ Application of blocking agent in preparation of medicine for treating cranial nerve arsenic poisoning. Background technique [0002] In recent years, the toxicity of arsenic has significantly affected human life and health. Long-term exposure to the environment containing arsenic and arsenic compounds will have many adverse effects on human health, including skin pigmentation, abnormal keratosis, respiratory diseases, gastrointestinal disorders, anemia and splenomegaly, related Birth defects, cardiovascular dysfunction, renal failure, etc. in newborns, while increasing the risk of lung cancer, skin cancer and other cancers in healthy people. Arsenic exposure in humans has many adverse health effects including not only increased risk of various forms of cancer and some benign diseases, but also neurological effects due to occupational or environmental exposure...

Claims

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Application Information

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IPC IPC(8): A61K31/4178A61K31/69A61P39/02A61P25/00
CPCA61K31/4178A61K31/69A61K2300/00
Inventor 姜玉峰吕海龙秦文娟
Owner 姜玉峰