The invention discloses a food-grade anti-wrinkle age-defying lotion, made from materials in following percent by weight: 10-20 % of all-natural milk, 7-11 % of all-natural olive oil, 4-8 % of glycerol, 3-7 % of glycerol monostearate, 5-7.5 % of fresh Cacumen Platycladi, 3-4.5 % of fresh Herba Portulacae, 1-1.5 % of fresh Flos Rosae Rugosae 0.5-0.75 % of fresh Fructus Forsythiae, 0.2-0.3 % of Pulvis Margarita, 0.1-0.15 % of Herba Menthae, 0.1-0.15 % of Herba Lysimachiae, 0.05-0.075 % of Folium Isatidis, 0.05-0.075 % of Radix Glycyrrhizae, 2-4 % of all-natural honey, 1.5-3.5 % of stearic acid, 1-3 % of almond extract oil, 1-3 % of hexadecanol, 0.2-0.4 % of tween-80, 0.08-0.12 % of propylparaben, 0.1-0.3 % of methylparaben, 0.08-0.12 % of an essence, and the balance of distilled water; in the formulation, the fresh Herba Portulacae can promote local blood circulation of skin and expansion of pores, the fresh Fructus Forsythiae is effective in diminishing inflammation, clearing heat, arresting pain, suppressing viruses and inhibiting elastinase activity and has effects of clearing heat and toxicity and subsiding swelling and expelling pus, the fresh Fructus Forsythiae with the Pulvis Margarita can care the skin, and the fresh Fructus Forsythiae and the Pulvis Margarita may then be compatible with other medicinal materials in the formulation to enable the effects of removing lead, mercury and arsenic poisoning of the skin.