Preparation method of rat metabolic syndrome model and feed used in method

A technology for metabolic syndrome and feed is applied in the field of preparation of a rat metabolic syndrome model, which can solve the problems of insignificant levels, elevated glucose metabolism in mice, and slow weight gain.

Inactive Publication Date: 2018-03-13
XINXIANG MEDICAL UNIV
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Problems solved by technology

At present, although there are different species and types of Mets experimental animal models, some animal models have problems such as expensive modeling, large inter-individual differences of Mets experimental animal mode...

Method used

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  • Preparation method of rat metabolic syndrome model and feed used in method
  • Preparation method of rat metabolic syndrome model and feed used in method
  • Preparation method of rat metabolic syndrome model and feed used in method

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Embodiment Construction

[0012] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0013] In the following examples, 20 8-week-old male Wistar rats of SPF grade used were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Blood glucose detector and test strips were purchased from Roche (Diagnostic Products) Shanghai Co., Ltd.; triglyceride (TG) kit, total cholesterol (TC) kit, low-density lipoprotein cholesterol (LDL) kit and high-density lipoprotein cholesterol (HDL) kits were purchased from Zhongsheng Beikong Biotechnology Co., Ltd.

[0014] Feed formula:

[0015] Control group: the standard rat feed is a commercially available rat pellet feed (Jiangsu Nantong Trofe Feed Technology Co., Ltd.), th...

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Abstract

The invention discloses a preparation method of a rat metabolic syndrome model and feed used in the method. The preparation method comprises the following steps that 8-week-old Wistar male rats are fed in an environment of 20-22 DEG C and illuminated for 12 hours every day, after adaptive feeding for one week, the rats are fed with the high-fat feed every day, and the rats are continuously fed forless than 18 weeks; the high-fat feed is prepared from, by weight, 60 parts of standard rat feed, 8 parts of egg yolk powder, 12 parts of lard oil, 12 pars of saccharose, 6 parts of peanut powder, 1part of powdered milk, 1 part of cholesterol, 0.01 part of bile salt from pigs, 3 parts of palm oil and 3 parts of coconut oil. The rats are fed with the high-fat feed for a long time, the lipid metabolism disorder and obesity of the Wistar rats are successfully induced, clinical features of metabolic syndromes appear, and the method is an effective method for building the rat metabolic syndrome model.

Description

technical field [0001] The invention relates to the field of biology, in particular to a method for preparing a rat metabolic syndrome model and the feed used. Background technique [0002] Metabolic syndrome (Metabolic syndrome, Mets) is a group of complex syndromes and metabolic abnormalities, including glucose metabolism disorders, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol and obesity; among the five criteria Mets can be diagnosed when three of them appear at the same time. Mets is considered to be closely related to the occurrence of diabetes and cardiovascular diseases; and studies have confirmed that: Mets can significantly increase the mortality rate of cardiovascular diseases, the incidence of disability and disability in the population. About 34% of adults in the United States are diagnosed with Mets; a population survey in Guangdong, my country in 2010 showed that the prevalence of Mets was 26.7%. As a result, Mets have become a...

Claims

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Application Information

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IPC IPC(8): A01K67/02A23K10/20A23K10/30A23K20/105A23K20/158A23K20/163A23K50/50
CPCA01K67/02A23K10/20A23K10/30A23K20/105A23K20/158A23K20/163A23K50/50
Inventor 丁世彬高丽云蒋金金
Owner XINXIANG MEDICAL UNIV
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