Preparation method of rat metabolic syndrome model and feed used in method

Abstract

The invention discloses a preparation method of a rat metabolic syndrome model and feed used in the method. The preparation method comprises the following steps that 8-week-old Wistar male rats are fed in an environment of 20-22 DEG C and illuminated for 12 hours every day, after adaptive feeding for one week, the rats are fed with the high-fat feed every day, and the rats are continuously fed forless than 18 weeks; the high-fat feed is prepared from, by weight, 60 parts of standard rat feed, 8 parts of egg yolk powder, 12 parts of lard oil, 12 pars of saccharose, 6 parts of peanut powder, 1part of powdered milk, 1 part of cholesterol, 0.01 part of bile salt from pigs, 3 parts of palm oil and 3 parts of coconut oil. The rats are fed with the high-fat feed for a long time, the lipid metabolism disorder and obesity of the Wistar rats are successfully induced, clinical features of metabolic syndromes appear, and the method is an effective method for building the rat metabolic syndrome model.

Description

technical field [0001] The invention relates to the field of biology, in particular to a method for preparing a rat metabolic syndrome model and the feed used. Background technique [0002] Metabolic syndrome (Metabolic syndrome, Mets) is a group of complex syndromes and metabolic abnormalities, including glucose metabolism disorders, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol and obesity; among the five criteria Mets can be diagnosed when three of them appear at the same time. Mets is considered to be closely related to the occurrence of diabetes and cardiovascular diseases; and studies have confirmed that: Mets can significantly increase the mortality rate of cardiovascular diseases, the incidence of disability and disability in the population. About 34% of adults in the United States are diagnosed with Mets; a population survey in Guangdong, my country in 2010 showed that the prevalence of Mets was 26.7%. As a result, Mets have become a...

AI Technical Summary

Problems solved by technology

At present, although there are different species and types of Mets experimental animal models, some animal models have problems such as expensive modeling, large inter-individual differences of Mets experimental animal models, and low success rate of screening.

In addition, there are mice Mets induced by high-fat diet, but long-term high-fat diet can only induce the level of glucose metabolism in mice is not obvious, and the body weight gain is slow

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