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A method of rapid tooth enamel mineralization

An enamel, fast technology, applied in dentistry, pharmaceutical formulations, dental preparations, etc., can solve the problems of pulp nerve cell apoptosis, pulp cavity heating, etc., to slow down the crystal nucleation rate, increase the reaction rate, and speed up the interface. nucleation effect

Active Publication Date: 2020-09-15
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But in hard tissue, due to the high penetration characteristics of laser, it is easy to heat the pulp cavity and cause the apoptosis of pulp nerve cells, so it is less used in hard tissue surgery

Method used

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  • A method of rapid tooth enamel mineralization
  • A method of rapid tooth enamel mineralization
  • A method of rapid tooth enamel mineralization

Examples

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Effect test

Embodiment 1

[0039] Example 1. A method for rapid enamel mineralization under physiological conditions

[0040] 1. Preparation of reagents: According to the molar ratio of Ca:P:F (calcium element: phosphorus element: fluorine element) in the final mineralization solution is 5:3:1, respectively prepare calcium chloride and dihydrogen phosphate with corresponding concentrations The reaction solution of sodium and sodium fluoride was stirred until completely dissolved.

[0041] The concentration of calcium ions in the final mineralization solution is set to three groups of 0.1M, 0.2M and 0.3M, and the three groups of mineralization solutions configured are marked as 1, 2 and 3 respectively.

[0042] 2. In the prepared calcium chloride solution, according to the molar ratio of Ca:HEDTA=1:1.1~1.2, dissolve HEDTA in the calcium chloride solution. In order to speed up the dissolution, adjust the pH value to between 3.0-6.0 during the dissolution process. Mix the prepared calcium chloride soluti...

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PUM

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Abstract

The invention discloses a method for rapidly mineralizing enamel. The method comprises the following steps: 1) mixing a calcium solution with a chelating agent, further mixing with a phosphate radicalsolution, and adjusting the pH value so as to obtain a mixed solution; 2) mixing the mixed solution with a fluorine solution so as to obtain a mineralizing solution, and performing separation and precipitation on the mineralizing solution; 3) putting a tooth of which the treatment surface faces upwards into the mineralizing solution, and submerging the tooth by the mineralizing solution; and 4) treating the treatment surface of the tooth with laser, thereby rapidly mineralizing the enamel of the treatment surface of the tooth. Through partial heating of laser, and with the chelating agent forinhibiting growth of crystal, the enamel can be rapidly mineralized.

Description

technical field [0001] The invention relates to a method for rapid tooth enamel mineralization, which belongs to the field of tissue engineering regeneration. Background technique [0002] Enamel is the outermost tissue of the tooth and the hardest tissue in the human body. Unlike other calcified tissues, however, enamel has no cellular components, so it cannot regenerate once damaged. In addition to affecting people's chewing of food, damaged tooth enamel is more likely to expose the pulp nerves to external environmental stimuli, causing various pains, or bacterial infections. Therefore, how to restore damaged enamel in vivo has become the focus of current research. [0003] At present, there are very few literatures on in vivo restoration of enamel. Most of them need to mix calcium ions and phosphate ions in a certain proportion to form a gel. Natural mineralization. However, the disadvantage of this method is that it takes a very long time. It usually takes 1-2 days ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/838A61K6/831A61K6/80
CPCA61K6/80A61K6/831A61K6/838
Inventor 陈海峰孙牧旸
Owner PEKING UNIV
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