Double-phase calcium phosphate material and toothpaste containing same

A calcium-phosphorus and toothpaste technology, applied in the field of tooth restoration, can solve problems such as poor effect, slow tooth restoration process, inability to quickly realize hydroxyapatite crystallization, etc., and achieve the effect of avoiding flushing loss and long-term tooth structure restoration.

Active Publication Date: 2021-06-04
谭生龙
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The invention provides a dual-phase calcium-phosphorus material and a toothpaste containing the dual-phase calcium-phosphorus material to solve or partially solve the problem that existing biologically active substances cannot quickly realize the crystallization of hydroxyapatite, resulting in slow tooth restoration process and insufficient effect good technical questions

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  • Double-phase calcium phosphate material and toothpaste containing same
  • Double-phase calcium phosphate material and toothpaste containing same
  • Double-phase calcium phosphate material and toothpaste containing same

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preparation example Construction

[0047] The above-mentioned embodiment provides a brand-new bioactive material: a dual-phase calcium-phosphorus material. Based on the same inventive concept as the above-mentioned embodiment, in another optional embodiment, a preparation of the above-mentioned dual-phase calcium-phosphorus material is provided. method, including the following steps:

[0048] S1: Prepare a calcium salt solution or Ca(OH) with a mass concentration of 1% to 20% 2 solution, adding glacial acetic acid during the stirring process, controlling the molar ratio of acetate and calcium ions to be 0.03-10:1 to obtain a mixed solution;

[0049] S2: Add dilute phosphoric acid with a mass percentage concentration of 1% to 30% to the mixed solution dropwise at a temperature of 15°C to 35°C until the pH value of the mixed solution is 5.0 to <7.0, and continue to stir the reaction after the addition is completed 1 ~16 hours to obtain emulsion;

[0050] S3: Centrifuge the emulsion, remove the supernatant, and ...

Embodiment 1

[0078] This embodiment provides a dual-phase calcium-phosphorus material, the preparation steps of which include:

[0079] The first step, configure Ca(OH) with 5% mass fraction 2 Emulsion 200mL, add 15mL glacial acetic acid under stirring, stir for about 1h;

[0080] In the second step, 130 mL of dilute phosphoric acid solution with a mass fraction of 14% was added dropwise at room temperature, and the drop was completed in 20 minutes, and the stirring speed was 500 r / min;

[0081] In the third step, continue to stir and react for 2 hours, then centrifuge, and wash the precipitate with deionized water until there is no obvious sour taste;

[0082] The fourth step is to dry the precipitate to obtain a dual-phase calcium-phosphorus material;

[0083] The TEM (transmission electron microscope) figure of the dual-phase calcium-phosphorus material prepared in this embodiment is as follows figure 1As shown, it can be seen that the nanoscale particle size of the prepared dual-pha...

Embodiment 2

[0090] This embodiment provides a dual-phase calcium-phosphorus material, the preparation steps of which include:

[0091] The first step, configure Ca(OH) with 8% mass fraction 2 Emulsion 160mL, add 30mL glacial acetic acid under stirring, stir for about 1h;

[0092] In the second step, 300 mL of dilute phosphoric acid solution with a mass fraction of 5% was added dropwise at room temperature, and the drop was completed in 40 minutes;

[0093] The third step is to continue the reaction for 3 hours, centrifuge, and wash the precipitate with deionized water until there is no obvious sour taste;

[0094] In the fourth step, the precipitate is dried to obtain a dual-phase calcium-phosphorus material.

[0095] Next, an anti-allergic / tooth restoration toothpaste is prepared by using the biphasic calcium-phosphorus material prepared above, and the mass percentage of the biphasic calcium-phosphorus material is 1% to 10%.

[0096] The material for preparing toothpaste is except two...

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Abstract

The invention discloses a double-phase calcium phosphate material. The double-phase calcium phosphate material comprises brushite and hydroxyapatite; the brushite is a main phase and is of a crystal-amorphous transition state structure, and the hydroxyapatite is a second phase; and the two-phase calcium phosphate material forms micron-sized particles with the particle size of 1-20 [mu]m and nanometer particles with the particle size of 10-200 nm. The micron-sized particles can be preliminarily filled to the surface of a damaged tooth structure, and are firmly combined with the tooth surface, so that washing loss is effectively avoided; and the nanometer particles entering the surface of the damaged tooth can rapidly form a hydroxyapatite structure by mineralizing, to further supplement an incompletely filled part, so that the effects of complete filling and sealing are achieved, and a complete and uniform hydroxyapatite protective layer is formed. The invention further provides toothpaste containing the double-phase calcium phosphate material, and the toothpaste has a rapid and long-lasting tooth structure repairing effect.

Description

technical field [0001] The present application relates to the technical field of tooth restoration, in particular to a dual-phase calcium-phosphorus material and a toothpaste containing the dual-phase calcium-phosphorus material. Background technique [0002] Teeth are mainly composed of the outermost layer of enamel and the inner layer of dentin. Tooth loss begins with damage to the enamel. Dental caries is the most common chronic disease that causes damage to tooth enamel. It is characterized by the dissolution of hydroxyapatite crystals, an inorganic component of tooth enamel, in the acidic environment produced by cariogenic bacteria. The further development of dental caries, resulting in the dissolution of minerals in the dentin layer, causes another condition - dentin hypersensitivity (DH). It is characterized by the transient appearance of exposed dentinal tubules in response to external stimuli, such as cold, heat or chemical factors. sharp pain. Unlike bone, ename...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/24A61Q11/00A61K33/42A61K9/12A61P1/02A61K6/838
CPCA61K8/24A61Q11/00A61K33/42A61K9/006A61P1/02A61K2800/412A61K2800/413A61K2300/00
Inventor 谭生龙
Owner 谭生龙
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