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Gastric signet ring cell carcinoma surgery incision flushing solution and preparation method thereof

A technique for signet ring cell carcinoma and surgical incisions, which is applied in the direction of antibacterial drugs, pharmaceutical formulas, and medical preparations with non-active ingredients, etc. It can solve the problems of high cost of surgical flushing fluid preparation, inability to effectively remove mucus, etc., and achieve enhanced sterilization effect, ensuring biological safety, and promoting incision healing

Active Publication Date: 2020-06-16
湖北华仁同济药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a flushing liquid for gastric signet ring cell carcinoma surgical incisions that promotes incision healing and effectively sterilizes the incisions, which solves the problem of ineffective removal of residual mucus produced by gastric signet ring cell carcinomas around the incisions in the prior art and surgical flushing. Technical problem of high liquid preparation cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A gastric signet ring cell carcinoma surgical incision flushing solution, comprising 1.1 g of mitomycin, 1.0 g of hydroxycamptothecin, 0.92 g of cyclosporine, 0.7 g of benzalkonium bromide, 5.3 g of sodium chloride, and sodium acetate trihydrate 3.7g, potassium chloride 0.37g, magnesium chloride hexahydrate 0.3, sodium gluconate 5.0g, pH 6.8, osmotic pressure 295mOsmol / L.

[0039] Its preparation method is

[0040] Strong match;

[0041] Add water for injection of 60% prescription quantity in the concentrated preparation tank, add prescription quantity sodium chloride, sodium acetate, potassium chloride, magnesium chloride, sodium gluconate, mitomycin, hydroxycamptothecin, cyclosporine, benzene Zonium bromide; after stirring and dissolving, add a concentrated volume of 0.1% (w / V) medicinal activated carbon, stir, heat-preserve and adsorb for 15 minutes, cool to 50°C, decarbonize through a 5um titanium rod for 15-20 minutes, and then Titanium rods are driven into dilut...

Embodiment 2

[0045] A gastric signet ring cell carcinoma surgical incision flushing solution, comprising 0.6 g of mitomycin, 1.2 g of hydroxycamptothecin, 1.0 g of cyclosporine, 0.9 g of benzalkonium bromide, 5.0 g of sodium chloride, and sodium acetate trihydrate 3.5g, potassium chloride 0.4g, magnesium chloride hexahydrate 0.2g, sodium gluconate 4.8g, pH is 6.9, osmotic pressure is 295mOsmol / L.

[0046] Its preparation method is

[0047] Strong match;

[0048] Add water for injection of 60% prescription quantity in the concentrated preparation tank, add prescription quantity sodium chloride, sodium acetate, potassium chloride, magnesium chloride, sodium gluconate, mitomycin, hydroxycamptothecin, cyclosporine, benzene Zonium bromide; after stirring and dissolving, add a concentrated volume of 0.1% (w / V) medicinal activated carbon, stir, heat-preserve and adsorb for 15 minutes, cool to 50°C, decarbonize through a 5um titanium rod for 15-20 minutes, and then Titanium rods are driven into ...

Embodiment 3

[0052] A gastric signet ring cell carcinoma surgical incision flushing solution, comprising 1.5 g of mitomycin, 0.9 g of hydroxycamptothecin, 0.8 g of cyclosporine, 0.5 g of benzalkonium bromide, 5.5 g of sodium chloride, and sodium acetate trihydrate 4.0g, potassium chloride 0.3g, magnesium chloride hexahydrate 0.4g, sodium gluconate 4.8g, pH is 6.7, osmotic pressure is 295mOsmol / L.

[0053] Its preparation method is

[0054] Strong match;

[0055] Add water for injection of 60% prescription quantity in the concentrated preparation tank, add prescription quantity sodium chloride, sodium acetate, potassium chloride, magnesium chloride, sodium gluconate, mitomycin, hydroxycamptothecin, cyclosporine, benzene Zonium bromide; after stirring and dissolving, add a concentrated volume of 0.1% (w / V) medicinal activated carbon, stir, heat-preserve and adsorb for 15 minutes, cool to 50°C, decarbonize through a 5um titanium rod for 15-20 minutes, and then Titanium rods are driven into ...

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PUM

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Abstract

The invention provides an operative incision rinse solution for gastric signet-ring cell carcinoma and a preparation method of the operative incision rinse solution and relates to the technical fieldof medical chemistry. The operative incision rinse solution comprises sodium chloride, sodium acetate trihydrate, potassium chloride, magnesium chloride hexahydrate, sodium gluconate, mitomycin, hydroxycamptothecine, ciclosporin and benzalkonium bromide. The preparation process comprises the following steps: concentrated preparation, namely adding water for injection with a prescription dosage of60% into a concentrated preparation tank, adding raw material components at the prescription dosage, stirring and dissolving, adding activated carbon to be stirred, maintaining the temperature and adsorbing, cooling, performing decarburization cycle with a titanium bar, pumping into a dilute preparation tank by virtue of the titanium bar, filling the water for injection to reach the total dose, stirring, detecting an intermediate to be qualified, performing circulating reflux on the liquid medicine through a filter element, filtering, filling and sterilizing; and dilute preparation, namely adding water for injection with a prescription dosage of 60% into a preparation tank, adding raw materials at the prescription dosage, stirring and dissolving, filling the water for injection to reach the total dose, stirring, detecting to be qualified, performing circulating reflux through the filter element, filtering, filling and sterilizing. The rinse solution provided by the invention has the beneficial effects of killing bacteria, clearing mucus, promoting curing and preventing adhesion.

Description

technical field [0001] The invention provides a gastric cancer surgical incision flushing solution and a preparation method thereof, in particular to a gastric signet ring cell carcinoma surgical incision flushing solution and a preparation method thereof, and relates to the technical field of medicinal chemistry. Background technique [0002] In order to pursue a clearer view during the surgical operation, it is necessary to flush the organs or tissues during the operation. After the operation is completed, the surgical area also needs to be flushed to remove bleeding residues. The flushing solution is often used as a carrier of drugs such as antibiotics to achieve local prevention. purpose of infection. Gastric signet ring cell carcinoma is a type of gastric cancer and one of the highly malignant tumors. It is a special gastric cancer that can secrete a large amount of mucus. In patients with gastric signet ring cell carcinoma, the cells are filled with mucus, which squeez...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/13A61K31/407A61K31/4745A61K31/14A61K9/08A61P31/04A61P31/02A61P17/02
CPCA61K9/0014A61K9/08A61K31/14A61K31/407A61K31/4745A61K38/13A61K47/26A61K2300/00
Inventor 冯新光宋群李继仁
Owner 湖北华仁同济药业有限责任公司
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