EGFR antibody having specific collagen binding ability, and application thereof in spinal cord injury repairing

A specific binding, collagen technology, applied in prostheses, hybrid peptides, specific peptides, etc., can solve problems such as side effects, and achieve the effect of promoting recovery, promoting maturity and functionalization

Active Publication Date: 2018-03-30
DUBU BIOSCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

Inventions described by Bjorkman et al., have shown that certain compounds called cobalt disulfide (CoS) are able to stimulate neurogenesis when used alone or together with other agents for promoting cellular growth on brain tissue. These compositions help improve how we develop new drugs like BrainStorm Cell Therapeutics®(BCT).

Problems solved by technology

This patented technical problem addressed in this patents relates to finding ways to improve the efficiency with which nerves are able to generate new connections during brain damage or degrade them over time without causing long term harmful consequences such as paraplegia.

Method used

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  • EGFR antibody having specific collagen binding ability, and application thereof in spinal cord injury repairing
  • EGFR antibody having specific collagen binding ability, and application thereof in spinal cord injury repairing
  • EGFR antibody having specific collagen binding ability, and application thereof in spinal cord injury repairing

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Embodiment Construction

[0041] In view of the deficiencies in the prior art, the invention of the present application has undergone long-term research and a lot of practice, and has constructed a collagen-binding ability by adopting the recombinant Fab fragment of the functional region of the collagen binding domain (CBD) and cetuximab. EGFR antibody (CBD-Fab antibody). The CBD-Fab antibody can specifically bind to the collagen material, so that the collagen material can be used as a carrier carrying cetuximab, and has the ability to promote the differentiation of neural stem cells into neurons.

[0042] The inventors of the present application have also conducted a large number of experiments, including: biologically combining CBD-Fab to collagen materials to form EGFR antibody-modified collagen materials with specific collagen binding ability. Experiments have proved that it can not only inhibit the formation of scars, but also Can block the inhibitory effect of nerve regeneration inhibitory molecu...

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Abstract

The invention discloses an EGFR antibody having a specific collagen binding ability, and an application thereof in spinal cord injury repairing. The EGFR antibody having specific collagen binding ability comprises a collagen binding region and a functional region Fab segment of a cetuximab monoclonal antibody, connected to the collagen binding region. A CBD-Fab antibody provided by the invention has a good ability to promote the differentiation of neural stem cells into neurons, and can be efficiently bound to a collagen material to form a functionalized collagen material, the functionalized collagen material can inhibit the formation of scars, and also can close the inhibitory effect of nerve regeneration inhibition molecules, and the CBD Fab antibody can be slowly released from the collagen material, so a suitable microenvironment is created to induce the differentiation of the endogenous neural stem cells into the neurons in order to promote further maturation and functionalizationand ultimately improve the recovery of biological behavioral functions.

Description

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Claims

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Application Information

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Owner DUBU BIOSCIENCES
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