Application of isovitexin to preparation of vascular dilation drugs

A vasodilator and drug technology, applied in the application field of Isovitexin in the preparation of vasodilator drugs, can solve problems such as no breakthrough progress

Inactive Publication Date: 2018-04-03
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of hypertension and its related vascular complications and / or complications mainly relies on western medicine, but there has been no breakthrough in the treatment of hypertension with traditional Chinese medicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of isovitexin to preparation of vascular dilation drugs
  • Application of isovitexin to preparation of vascular dilation drugs
  • Application of isovitexin to preparation of vascular dilation drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound Isovitexin tablet involved in the present invention:

[0014] Take 5 grams of compound Isovitexin, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0015] Embodiment 2: the preparation of compound Isovitexin capsules involved in the present invention:

[0016] Take 5 grams of compound Isovitexin, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0018] Experimental example 1 Preparation of isolated rat aortic ring

[0019] Experimental procedure: clean grade male Sprague=Dawley (SD) rats, weighing 240-260 g. Rapidly dissociate the thoracic aorta of SD rats and place at 4°C containing 95% O 2 and 5% CO 2 In the K-H liquid pre-saturated with mixed gas, the surrounding connective tissue was removed and cut into vascular rings of 3-4 mm. During this period, care should be taken to protect the intima of the vascular ring from damage. According to the needs of the experiment, the method of rubbing the inner surface of the vascular ring with a cotton swab was used to prepare a part of the vascular ring as a model in which the endothelium was removed. Then the vascular ring was suspended in a bath pre-prepared with 10mL K-H solution, one end was fixed, and the other end was connected to the Medlab biological signal acquisition system through a tension transducer. In continuous pass 95% O2 and 5% CO 2 In the state of mixed...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention improves the application of Isovitexin in the preparation of vasodilator drugs, and the application of the Isovitexin in the preparation of blood pressure-lowering, anti-angina pectoris and other vascular disease drugs. The use of Isovitexin in the preparation of vasodilator drugs involved in the present invention is disclosed for the first time. Since the skeleton type is a brand-new skeleton type, its vasodilator activity is unexpectedly strong, and there is no possibility of any inspiration from other compounds, and it has outstanding essence Sexual characteristics, while being used to dilate blood vessels obviously has significant progress.

Description

technical field [0001] The present invention relates to a new application of compound Isovitexin, in particular to the application of Isovitexin in the preparation of vasodilators. Background technique [0002] In my country, hypertension is a common cardiovascular disease with a high prevalence rate, and the complications and / or comorbidities of heart, brain, kidney, limbs and other vascular complications and / or comorbidities rank first among all kinds of diseases , is extremely harmful to human health. According to the national census results in 1991, the prevalence rate of hypertension in my country increased by 275% within 13 months. At present, the treatment of hypertension and its related vascular complications and / or comorbidities mainly relies on western medicine, but there has been no breakthrough in the treatment of hypertension with traditional Chinese medicine. [0003] The compound Isovitexin involved in the present invention is a new compound published in 2013...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/48A61K9/20A61P9/08
CPCA61K31/352A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap