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Application of zinc ion specific binding peptide and its composition in preventing or treating Alzheimer's disease

A specific and peptide-binding technology, which is applied in the field of biomedicine, can solve the problems of high toxicity and side effects and the inability to penetrate the blood-brain barrier, and achieve the effects of low toxicity and side effects, good biocompatibility, and reducing the formation of senile plaques

Active Publication Date: 2020-09-29
NORTHEASTERN UNIV LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as mentioned above, there are generally problems such as high toxicity and side effects, and inability to pass through the blood-brain barrier.

Method used

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  • Application of zinc ion specific binding peptide and its composition in preventing or treating Alzheimer's disease
  • Application of zinc ion specific binding peptide and its composition in preventing or treating Alzheimer's disease
  • Application of zinc ion specific binding peptide and its composition in preventing or treating Alzheimer's disease

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Embodiment Construction

[0020] The present invention will be described in further detail below in conjunction with specific examples, which are explanations of the present invention rather than limitations.

[0021] In the first aspect, specific embodiments of the present invention provide a zinc ion-specific binding peptide having the following amino acid sequence:

[0022] His-Met-Gln-Thr-Asn-His-His.

[0023] The above-mentioned zinc ion-specific binding peptide can specifically bind zinc ions with high binding strength, has good biocompatibility, can pass through the blood-brain barrier quickly, and effectively reduces the formation of senile plaques. Therefore, it can be used in Alzheimer's disease Prevention or treatment of Alzheimer's disease.

[0024] Therefore, in the second aspect, specific embodiments of the present invention provide the use of the above-mentioned zinc ion-specific binding peptide for preventing or treating Alzheimer's disease.

[0025] The "prevention" refers to reducin...

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Abstract

The invention provides a zinc ion-specific binding peptide and its composition for use in preventing or treating Alzheimer's disease. The amino acid sequence of the zinc ion-specific binding peptide is: His-Met-Gln-Thr-Asn ‑His‑His, as shown in SEQ ID NO:1. The results of ELISA test, immunofluorescence test, Alzheimer's disease mouse in vivo experiment and other results show that the zinc ion-specific binding peptide of the present invention has high affinity for zinc ions, good specificity, low toxic and side effects, and It can reduce the formation of age spots by binding excess free zinc ions, so it has a certain effect in preventing or treating Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a zinc ion-specific binding peptide, in particular to the application of a zinc ion-specific binding peptide and a composition thereof in preventing or treating Alzheimer's disease. Background technique [0002] The incidence of Alzheimer's disease (AD) is increasing year by year, and it has become one of the major diseases that seriously threaten the health and quality of life of the elderly. In addition, it is gradually showing a younger trend, which has a great impact on the quality of life of patients and their families, and also brings great pressure to society. The treatment of AD has become an important problem to be solved urgently. [0003] The amyloid hypothesis has been the focus of AD research for more than 20 years. In addition to the use of neuroprotective agents for AD treatment, most drug development focuses on the clearance of abnormally folded proteins. Howe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/64A61K33/30A61P25/28
CPCA61K33/30
Inventor 张晓雨高慧玲钟曼丽王占友
Owner NORTHEASTERN UNIV LIAONING