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Transdermal drug delivery preparation used for treating liver cancer, and preparation method thereof

A technology for skin drug delivery and products, which is applied in the field of transdermal drug delivery products and preparations for liver cancer. It can solve the problems of decreased body function, low quality of life, and decreased immunity, etc., to improve drug efficacy, promote cell detoxification, and inhibit development. Effect

Inactive Publication Date: 2018-04-10
中山市择朋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various treatment methods have their advantages, disadvantages and indications, and all have different degrees of side effects
For example, patients after TACE are often complicated with fever, pain, vomiting and liver function damage, and the postoperative quality of life is low, the body function is significantly reduced, and the immunity is reduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1. No. 1 transdermal preparation for liver cancer

[0071] Good ratio of raw materials 1: five-flowered snake 8, red snake 15, viper 12, centipede 12, scorpion 15, flea 12, hedyotis diffusa 8, goldenrod 12, lobelia 12, barbata 15 , Nanling Yaohua 8;

[0072] Step 1. Water is inactivated in an ultra-high pressure cooker at 30°C and 600mpa for 10 minutes. After completion, 19 liters of it are injected into a sterile fermenter through a sterile silica gel pipeline for later use.

[0073] Step 2. Extract the water extract of traditional Chinese medicine:

[0074] The well-proportioned raw materials are packed in a 100-mesh filter, and the hydrogen-rich water and the well-proportioned raw materials are added to the ultra-high pressure cooker, with a weight ratio of 4:1;

[0075] Treat at 30°C and 800mpa for 30 minutes to extract the stock solution of traditional Chinese medicine.

[0076] Step 3: Co-fermentation

[0077] Inject 80L of the traditional Chinese medi...

Embodiment 2

[0082] Example 2. No. 2 transdermal drug product for liver cancer

[0083] Raw materials with good ratio 2: five-flowered snake 10, red snake 10, viper 10, centipede 10, scorpion 10, flea 10, diffusa 10, goldenrod 10, lobelia 10, barbata 10 , Nanling Yaohua 10;

[0084] Step 1. Water is inactivated in an ultra-high pressure cooker at 25°C and 600mpa for 5 minutes. After completion, 10 liters of it are injected into a sterile fermenter through a sterile silica gel pipeline for later use.

[0085] Step 2. Extract the water extract of traditional Chinese medicine:

[0086] The well-proportioned raw materials are packed in a 100-mesh filter, and the hydrogen-rich water and the well-proportioned raw materials are added to the ultra-high pressure cooker, with a weight ratio of 3:1;

[0087] Treat at 25°C and 800mpa for 50 minutes to extract the stock solution of traditional Chinese medicine.

[0088] Step 3: Co-fermentation

[0089] Inject 65L of the traditional Chinese medicine...

Embodiment 3

[0094] Example 3. No. 3 transdermal drug product for liver cancer

[0095] Good ratio of raw materials 3: five-flowered snake 12, red snake 8, viper 15, centipede 8, scorpion 12, flea 8, hedyotis diffusa 12, goldenrod 15, lobelia 8, barbata 12 , Nanling Yaohua 15;

[0096] Step 1. Hydrogen-rich water (Hitian Tianling water) is inactivated in an ultra-high pressure cooker at 28°C and 600mpa for 7 minutes. After completion, 25 liters of it are injected into a sterile fermenter through a sterile silica gel pipeline for later use.

[0097] Step 2. Extract the water extract of traditional Chinese medicine:

[0098] The well-proportioned raw materials are packed in a 100-mesh filter, and the hydrogen-rich water and the well-proportioned raw materials are added to the ultra-high pressure cooker, with a weight ratio of 6:1;

[0099] Treat at 35°C and 800mpa for 40 minutes to extract the stock solution of traditional Chinese medicine.

[0100] Step 3: Co-fermentation

[0101] Injec...

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PUM

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Abstract

The invention discloses a transdermal drug delivery preparation used for treating liver cancer, a traditional Chinese medicine raw material composition, and a preparation method of the transdermal drug delivery preparation, and belongs to the field of traditional Chinese medicine and pharmacy. The transdermal drug delivery preparation is a product obtained via co-fermentation of water extracts offollowing bulk drugs and Morchella esculenta mother liquor; the bulk drugs comprise, by weight, 8 to 15 parts of Dienagkistrodon acutus, 8 to 15 parts of dinodon rufozonatum, 8 to 15 parts of agkistrodon acutus, 8 to 15 parts of centipede, 8 to 15 parts of scorpion, 8 to 15 parts of manyleaf paris rhizome, 8 to 15 parts of spreading hedyotis herb, 8 to 15 parts of Solidago decurrens, 8 to 15 partsof Herba Lobeliae Chinensis, 8 to 15 parts of Herba Scutellariae Barbatae, and 8 to 15 parts of wikstroemia indica. The bulk drugs are extracted with hydrogen-enriched water, and mineral water from hita is taken as an extraction solvent preferably. The transdermal drug delivery preparation is capable of inhibiting liver cancer, relieving complication obviously, and improving patient quality of life.

Description

technical field [0001] The invention relates to a traditional Chinese medicine product and its processing technology, in particular to a transdermal drug product and a preparation method for liver cancer. technical background [0002] Cancer belongs to the category of "obsessed block" and "liver accumulation" in traditional Chinese medicine. It is mostly caused by emotional disorders, injury from diet, exogenous pathogens such as hepatitis B virus, damage to liver and spleen, and disharmony of viscera. Chinese medicine believes that external pathogens invade the body, and the confrontation between good and evil interacts with the internal organs and meridians. The incidence of liver cancer in my country is about 25.7 / 100,000, making it the third largest malignant tumor in terms of mortality after gastric cancer and lung cancer. Moreover, the incidence of liver cancer in my country is closely related to the infection rate of hepatitis B virus. More than 80% of liver cancers ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P1/16A61P35/00A61K35/648A61K35/646A61K35/583
CPCA61K9/0014A61K35/583A61K35/646A61K35/648A61K36/062A61K36/28A61K36/34A61K36/539A61K36/748A61K36/83A61K36/896A61K2236/19A61K2236/331A61K2236/51A61K2300/00
Inventor 彭鹏李泽文郑永琴彭都
Owner 中山市择朋生物科技有限公司
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