Application of astragalus flavonoid extract to preparation of drug for treating nephrotic syndrome

A technology for nephrotic syndrome and astragalus flavonoids is applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of unclear active ingredients, limited efficacy and the like, and achieves low cost, lower urine protein level, and simple extraction process. Effect

Inactive Publication Date: 2018-05-18
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, although Astragalus and Astragalus injection can improve nephrotic syndrome, their active ingredients are still unclear, and their efficacy is limited. In addition, there are no reports on the effects of Astragalus flavonoids and its extracts on nephrotic syndrome , the extracts mainly composed of the above active ingredients have not been reported for the treatment of nephrotic syndrome

Method used

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  • Application of astragalus flavonoid extract to preparation of drug for treating nephrotic syndrome
  • Application of astragalus flavonoid extract to preparation of drug for treating nephrotic syndrome
  • Application of astragalus flavonoid extract to preparation of drug for treating nephrotic syndrome

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Experimental program
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Effect test

Embodiment 1

[0016] The preparation of embodiment 1 Astragalus flavonoids extract

[0017] Take 3000g of Radix Astragali, crush it, add 8L of water, heat and reflux for extraction 3 times, each time for 1 hour, combine the obtained extracts, concentrate under reduced pressure to obtain a paste. Separate the above paste with AB-8 macroporous adsorption resin column, elute with water, 10%, and 35% ethanol in sequence, collect the 35% ethanol eluate, concentrate and dry under reduced pressure, and concentrate the above 35% ethanol eluate The product was dispersed in 200mL of water, extracted twice with 1 times the volume of ethyl acetate, the extracts were combined, concentrated under reduced pressure to obtain an extract, and dried in vacuo at 60°C to obtain 3375mg of astragalus flavonoids extract.

Embodiment 2

[0018] The preparation of embodiment 2 astragalus flavonoids extract

[0019] Take 1000 g of Radix Astragali, add 8 L of 20% ethanol, heat and reflux for extraction twice, each time for 2 hours, combine the obtained extracts, concentrate under reduced pressure to obtain a paste. Separate the above paste with AB-8 macroporous adsorption resin column, elute with water, 10%, and 35% ethanol in sequence, collect the 35% ethanol eluate, concentrate and dry under reduced pressure, and concentrate the above 35% ethanol eluate The product was dispersed in 200mL water, extracted once with 2 times the volume of ethyl acetate, the extracts were combined, concentrated under reduced pressure to obtain an extract, and dried in vacuo at 60°C to obtain 943 mg of astragalus flavonoids extract.

Embodiment 3

[0020] The preparation of embodiment 3 astragalus flavonoids extract

[0021] Take 1000 g of Radix Astragali, add 8 L of 95% ethanol, heat and reflux for extraction twice, each time for 1 hour, combine the obtained extracts, concentrate under reduced pressure to obtain a paste. Separate the above paste with AB-8 macroporous adsorption resin column, elute with water, 10%, and 35% ethanol in sequence, collect the 35% ethanol eluate, concentrate and dry under reduced pressure, and concentrate the above 35% ethanol eluate The product was dispersed in 200mL of water, extracted twice with 2 times the volume of ethyl acetate, the extracts were combined, concentrated under reduced pressure to obtain an extract, and dried in vacuo at 60°C to obtain 1064 mg of astragalus flavonoids extract.

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Abstract

The invention provides application of an astragalus flavonoid extract to preparation of a drug for treating the nephrotic syndrome. The content of flavonoids in the astragalus flavonoid extract is 40-60 percent, and the astragalus flavonoid extract comprises the following main chemical components: formononetin, ononin, calycosin, calycosin-7-O-beta-D-glucopyranose, 7,2'-dihydroxy-3',4'-dimethoxyisoflavan, 2'-hydroxy-3',4'-dimethoxyisoflavan-7-O-beta-D-glucopyranose, 3-hydroxyl-9,10- dimethoxypterocarpan and 9,10-dimethoxypterocarpan-3-O-beta-D-glucopyranose. The astragalus flavonoid extract has a better improvement effect on nephrotic syndrome rats and can be used for preparing the drug for treating the nephrotic syndrome.

Description

technical field [0001] The invention relates to a new application of the astragalus flavone extract, in particular to the application of the astragalus flavone extract in the preparation of medicines for treating nephrotic syndrome. Background technique [0002] Nephrotic syndrome is a syndrome caused by changes in the permeability of the glomerular filtration membrane due to various causes. A large amount of urine protein is its main feature and cause. The high blood pressure and high blood fat caused by it will promote glomerular sclerosis. And a variety of glomerular diseases can cause nephrotic syndrome, systemic diseases and certain connective tissue diseases, such as infection, chronic inflammatory state, malignant tumor, drugs and plasma cell dyscrasia can cause nephrotic syndrome. [0003] The treatment of nephrotic syndrome is mainly to effectively control it by suppressing immune and inflammatory responses, including glucocorticoid therapy, cytotoxic drugs, and imm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P13/12
CPCA61K36/481A61K2236/333A61K2236/55
Inventor 李震宇齐彦爽张王宁李爱平高继宁李红秦雪梅
Owner SHANXI UNIV
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