Benzofuran derivative and application thereof

A technology of benzofuran and its derivatives, which is applied in the direction of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., and can solve the problem of not finding ingredients with particularly significant activity

Inactive Publication Date: 2010-07-14
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the end of the 1930s, many scholars at home and abroad have carried out a large number of studies on the chemical constituents of Fructus Rhododendron, and have identified a variety of chemical constituents such as alkaloids, flavonoids, sterols, etc., which have curative effects on renal insufficiency. No particularly active ingredients were found

Method used

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  • Benzofuran derivative and application thereof
  • Benzofuran derivative and application thereof
  • Benzofuran derivative and application thereof

Examples

Experimental program
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Effect test

example 1

[0069] Example 1: Extraction and separation of the compound of the present invention from the branch of Prunus chinensis.

[0070] Dried the whole herb [Lespedeza virgata (Thurb)] DC 40kg with the stalks of stalks, crushed, extracted by percolation with 95% ethanol, combined the extracts, recovered the ethanol in the extracts to obtain extracts, and the obtained extracts were firstly used with petroleum ether Extraction, take the water phase, then extract with chloroform, take the water phase, then extract with ethyl acetate, take the water phase, and finally extract with n-butanol, pass the n-butanol part through the forward silica gel column, and use the volume ratio respectively 98:2 , 95:5, 9:1 mixture of chloroform and methanol for gradient elution, collect the eluate with a volume ratio of chloroform and methanol of 9:1, and perform ODS reverse column chromatography, using concentrations of 30%, 50%, and 60% methanol gradient elution, collect the eluate of 60% methanol, ...

example 2

[0075] Example 2: (injection)

[0076] The compound obtained in Example 1 was made into an injection by the preparation method of a medicinal injection: 1000 mg of the compound was dissolved in 1000 ml of normal saline, heated to dissolve, mixed evenly, poured into a bottle, sealed, and sterilized to make 2 mg / 2 ml One injection. This product is used for intravenous injection (iv.), 6mg / day for adults, equivalent to 3 vials; usual dose for children: 0.05mg / kg / day based on body weight.

example 3

[0077] Example 3: (injection)

[0078] The compound obtained in Example 1 was prepared as an injection by the preparation method of a medicinal injection. Dissolve 2000 mg of this compound in 1000 ml of normal saline, heat to dissolve, mix well, pour into a bottle, seal, and sterilize to make 4 mg / 2 ml One injection. This product is used for intravenous injection (iv.), 6mg / day for adults, equivalent to 1.5 vials; usual dose for children: 0.05mg / kg / day according to body weight.

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Abstract

A 2-(6-hydroxy-2', 3'-dimethoxy-phenyl)-6-hydroxy-methoxy-Benfuran derivative is separated from (Lespedeza virgata(Thurb)DC), molecular formula is C17H1606, molecular weight is 316, it yellow green irregular powders. It has anti-oxidation function and can be used to treat nephritis.

Description

technical field [0001] The invention relates to the field of organic chemistry, in particular to furan compounds, in particular to a new benzofuran derivative. Background technique [0002] Prunus edulis is the whole herb of the genus Lespedeza virgata (Thurb) DC in the family Fabaceae, and it is widely distributed in various provinces and regions of the country. The medicinal value of the plants of the genus Escutellaria has been recorded in "Rescue Famine Materia Medica", "Classification of Herbal Medicine", and "Southern Yunnan Materia Medica". Its stems, leaves and roots are used as medicine, with slightly bitter taste, flat nature, and strong tendons Kidney, invigorating the spleen and removing dampness, moistening the lungs and clearing away heat, is widely used among the people. It is a commonly used medicinal material for the treatment of nephritis among the people in Hubei. It is used to treat chronic glomerulonephritis, pyelonephritis and other diseases. The main ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/86A61K31/343A61K36/48A61P13/12
Inventor 邓虹珠陈艳王彩云马骥易延逵
Owner SOUTHERN MEDICAL UNIVERSITY
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