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A method for extracting double demethoxy curcumin from turmeric

A technology of bis-demethoxycurcumin and curcumin, which is applied in the separation/purification of carbonyl compounds, organic chemistry and other directions, can solve the problems of high difficulty in resin processing, long cycle and small output, and achieves low cost and easy operation. , the effect of high purity

Active Publication Date: 2021-06-22
河北泽华生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of difficult resin treatment, high cost, small output and long cycle in the prior art, the present invention provides a method for extracting bisdemethoxycurcumin from turmeric

Method used

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  • A method for extracting double demethoxy curcumin from turmeric

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Embodiment 1

[0041] A method for extracting bisdemethoxy curcumin from turmeric, comprising the following steps:

[0042] (1) Mix turmeric powder and ethanol in a ratio of 1kg:4L by weight to volume, and carry out continuous countercurrent ultrasonic extraction for 2 hours at 30°C to obtain a turmeric extract;

[0043] (2) Concentrating the turmeric extract under reduced pressure for 2 hours at a temperature of 70° C. and a vacuum of -0.075 to -0.09 MPa, reclaiming the ethanol solvent, and obtaining crude curcumin;

[0044] (3) mixing the curcumin crude product with ethanol in a ratio of 1kg:4L by weight to volume, and extracting at 40°C for 2h to obtain a curcumin extract;

[0045] (4) Concentrate the curcumin extract under reduced pressure for 3 hours at a temperature of 80° C. and a vacuum of -0.075 to -0.09 MPa, reclaim the ethanol solvent, and obtain curcumin;

[0046] (5) Mix the mixed solvent of ether and ethanol with a volume ratio of 1:10 with the curcumin, adjust the temperature...

Embodiment 2

[0049] A method for extracting bisdemethoxy curcumin from turmeric, comprising the following steps:

[0050] (1) Mix turmeric powder and ethanol in a ratio of 1kg:3L by weight to volume, and carry out continuous countercurrent ultrasonic extraction for 3 hours at 20°C to obtain a turmeric extract;

[0051] (2) Concentrating the turmeric extract under reduced pressure for 1 h at a temperature of 70° C. and a vacuum of -0.075 to -0.09 MPa, reclaiming the ethanol solvent, and obtaining crude curcumin;

[0052] (3) mixing the curcumin crude product with ethanol in a ratio of 1kg:5L by weight to volume, and extracting at 50°C for 3h to obtain a curcumin extract;

[0053] (4) Concentrating the curcumin extract under reduced pressure for 2 hours at a temperature of 70° C. and a vacuum of -0.075 to -0.09 MPa, reclaiming the ethanol solvent, and obtaining curcumin;

[0054] (5) Mix the mixed solvent of ether and ethanol with a volume ratio of 1:5 with the curcumin, adjust the temperat...

Embodiment 3

[0057]A method for extracting bisdemethoxy curcumin from turmeric, comprising the following steps:

[0058] (1) Mix turmeric powder and ethanol in a ratio of 1kg:5L by weight to volume, and carry out continuous countercurrent ultrasonic extraction for 3 hours at 25°C to obtain a turmeric extract;

[0059] (2) Concentrating the turmeric extract under reduced pressure for 2 hours at a temperature of 80° C. and a vacuum of -0.075 to -0.09 MPa, reclaiming the ethanol solvent, and obtaining crude curcumin;

[0060] (3) mixing the curcumin crude product with ethanol in a ratio of 1kg:6L by weight to volume, and extracting at 60°C for 2h to obtain a curcumin extract;

[0061] (4) Concentrating the curcumin extract under reduced pressure for 1 h at a temperature of 70° C. and a vacuum of -0.075 to -0.09 MPa, reclaiming the ethanol solvent, and obtaining curcumin;

[0062] (5) Mix the mixed solvent of ether and ethanol with a volume ratio of 1:8 with the curcumin, adjust the temperatu...

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Abstract

The invention relates to the technical field of traditional Chinese medicine phytochemistry, and specifically discloses a method for extracting bisdemethoxycurcumin from turmeric. The method for extracting bis-demethoxy curcumin from turmeric comprises the following steps: dispersing turmeric powder in an extraction agent, performing continuous countercurrent ultrasonic extraction treatment to obtain a turmeric extract; Concentrating under reduced pressure to obtain crude curcumin; adding the first extractant to the crude curcumin for extraction to obtain a curcumin extract; subjecting the curcumin extract to concentration under reduced pressure to obtain curcumin; The second extractant is mixed with the curcumin, extracted, crystallized, filtered and dried to obtain bisdemethoxy curcumin. The method for extracting bisdemethoxycurcumin from turmeric in the present invention has simple process, convenient operation, low cost and high efficiency, and can effectively separate bisdemethoxycurcumin from curcumin with high purity. Industrialized production is possible.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine phytochemistry, in particular to a method for extracting bisdemethoxycurcumin from turmeric. Background technique [0002] Curcumin is extracted from the rhizomes of some plants in Zingiberaceae and Araceae. Curcumin is an orange-yellow crystalline powder with a slightly bitter taste and is insoluble in water. Turmeric is mainly composed of curcumin and turmeric volatile oil. Curcumin contains three main components, namely curcumin I (40%), demethoxycurcumin II (25%) and demethoxycurcumin III ( 35%) three-component composition. [0003] In terms of medical applications, demethoxycurcumin (bisdemethoxycurcumin) has anti-oxidation, anti-cancer, elimination of free radicals, lipid-lowering and pharmacological effects on the digestive system and cardiovascular system. [0004] At present, there are many methods for extracting and purifying dedimethoxycurcumin, each with its own...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/248C07C45/78C07C45/80C07C45/81
CPCC07C45/78C07C45/80C07C45/81C07C49/248
Inventor 于凯侯德强冯玲
Owner 河北泽华生物科技有限公司